功能性消化不良患者阻抗式胃动力分析  

Analysis of impedance gastric motility of patients with functional dyspepsia

作　　者：罗访[1,2] 刘纯伦[1] 李章勇[3] 

机构地区：[1]重庆医科大学附属第一医院消化内科,重庆400016 [2]重庆医科大学社区医疗中心内科 [3]重庆邮电大学生物信息学院,重庆400065

出　　处：《解放军医学杂志》2010年第12期1478-1480,共3页Medical Journal of Chinese People's Liberation Army

基　　金：国家自然科学基金资助项目(60471041)

摘　　要：目的通过对功能性消化不良(FD)患者进行胃电和胃阻抗特征分析,探讨罗马Ⅲ分型的意义。方法重庆医科大学附属第一医院消化内科2008年10月-2009年12月期间的门诊FD患者162例,包括餐后不适综合征(PDS组)99例和上腹疼痛综合征(EPS组)63例,另设健康对照32例。采用阻抗式胃动力检测仪测定胃电和胃阻抗,分析FD及其亚型的发病机制。结果与健康对照者胃电和胃阻抗比较,FD患者中频节律分布百分比明显降低。PDS组以低频节律分布百分比增高为主,EPS组以高频节律分布百分比增高为主。PDS组胃电和胃阻抗低频节律分布百分比显著高于EPS组(P<0.017),两组胃电中频节律分布百分比比较无显著性差异。PDS组胃阻抗中频节律分布百分比显著低于EPS组,而胃电和胃阻抗高频节律分布百分比均显著低于EPS组(P<0.017)。结论胃动力障碍是FD的发病机制之一,PDS和EPS患者发病机制存在差异,罗马Ⅲ分型有利于治疗方案的选择。Objective To investigate the significance of RomeⅢclassification by analyzing the characteristics of gastric electrical activity and gastric impedance of patients with functional dyspepsia（FD）.Methods One hundred and sixty-two outpatients with FD visiting our hospital from Oct.2008to Dec.2009were divided into PDS group（postprandial distress syndrome patients,n=99）and EPS group（epigastric pain syndrome patients,n=63）,and 32healthy people were entered as controls.The postprandial electrical signal and impedance signal were determined by impedance gastric motility instrument.The pathogenesis of FD and its subtypes were analyzed.Results Compared with that in healthy people,the distribution percentage of intermediate frequency（IF）gastric electrical activity was decreased significantly,that of low frequency（LF）gastric electrical activity was increased in PDS group,while that of the high frequency（HF）gastric electrical activity was increased significantly in EPS group.The distribution percentage of LF gastric electrical activity was higher,and that of HF gastric electrical activity was lower significantly in PDS group than in EPS group（P〈0.017）,but no obvious difference was found between the two groups in the distribution percentage of IF gastric electrical activity.The distribution percentage of LF gastric impedance was higher,while the IF and HF gastric impedance were lower significantly in PDS group than in EPS group（P〈0.017）.Conclusions Gastric motility disorder is one of the pathogenetic factors of FD.The pathogenesis of PDS is different from that of EPS,so the classification of RomeⅢmay be beneficial for the option of treatment stratigy FD.

关 键 词：消化不良 罗马Ⅲ诊断标准 胃电描记术 电阻抗 

分 类 号：R573[医药卫生—消化系统]