胰岛素抵抗与良性前列腺增生的相关性研究  

Research on correlation between insulin resistance and benign prostate hyperplasia

作　　者：陈振勇[1] 陈晓春[1] 黄文广[1] 杨鹏[1] 周有生[1] 肖虹[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院老年病科,武汉430022

出　　处：《中华老年医学杂志》2010年第11期888-890,共3页Chinese Journal of Geriatrics

摘　　要：目的 探讨胰岛素抵抗与良性前列腺增生间（BPH）的关系. 方法 选取在我院行健康体检老年男性200例,根据前列腺体积（PV）分为对照组（PV≤20 ml）100例,BPHl组（PV 21～49ml）50例,BPH2组（PV≥50 ml）50例.采用己糖激酶法测定空腹血糖（FPG）,放免法测定空腹胰岛素（FSI）水平,运用HOMA模型计算胰岛素抵抗指数（IRI）;测量身高和体质量,并计算体质指数.结果 BPH1组IRI（1.10±0.18）和体质指数（22.0±3.0）与对照组（1.18±0.21和21.8±2.7）比较,差异无统计学意义（均P＞0.05）;BPH2组IRI（1.31±0.19）和体质指数（24.8±3.29）较对照组明显增高（P=0.01,0.03）.高血糖所占比例BPH组（25%）高于对照组（5%）（P=0.00）,其中BPH2组高血糖所占比例更高（36%）（P=0.01）;BPH2组高血糖组IRI（1.47±0.21）较对照组（1.34±0.18）明显增高（t=3.92,P=0.00）,但体质指数（25.8±4.3）kg/m2与对照组（24.3±2.7）kg/m2比较,差异无统计学意义（t=0.06,P=0.95）. 结论 高血糖和胰岛素抵抗与重度前列腺增生存在相关性,且胰岛素抵抗的存在不依赖于体质指数的改变.Objective To investigate the correlation of insulin resistance （IR） and benign prostate hyperplasia （BPH）. Methods The 200 health examination men were divided into three groups according to the prostate volume （PV）. There were 100 healthy subjects as control group （PV≤20 ml）, 50 cases in BPH1 group （20 ml〈PV〈50 ml） and 50 cases in BPH2 group （PV≥50 ml）.The fasting blood glucose （FBG） and fasting serum insulin （FSI） were determined using hexokinase method and radioimmunoassy, respectively. The IR index （IRI） and body mass index （BMI） were calculated according to the formula in HOMA model. Results There were no statistical differences between BPHl group and healthy control group in IRI （1.10±0. 18 vs. 1.18±0.21） and BMI （22. 0±3.0vs. 21.8±2.7） （t=0.74, 0.18, both P〉0. 05）, but the IRI （1.31±0.19） and BMI （24. 8±3.29） increased in BPH2 group （P=0. 01, 0.03）. The percentage of hyperglycosemia was higher in BPH patients than in normal controls （25% vs. 5%, P = 0. 00）. Of them, the percentage of hyperglycosemia was the highest in BPH2 group （36%, P = 0. 01 ）, their IRI （ 1.47 ± 0.21 ） was higher than in euglycemia patients （t=3.92, P=0.00）, but the BM1 was unchanged compared with the control group （ 25.8 ± 4.3 vs. 24.3 ± 2.71, P = 0. 95 ）. Conclusions There is a positive correlation of IR and hyperglycosemia with severe BPH, and the IR in severe BPH is independent of BMI.

关 键 词：胰岛素抵抗 前列腺增生 体质指数 

分 类 号：R686[医药卫生—骨科学]