Optimization of the Process of Gelatin-ceftiofur Sodium Microspheres  

作　　者：郝智慧 肖希龙 

机构地区：[1]Department of Pharmacology and Toxicology,College of Veterinary Medicine,China Agricultural University [2]Qingdao KDN Animal Drugs Technology Development Research Center

出　　处：《Journal of Wuhan University of Technology(Materials Science)》2010年第6期975-978,共4页武汉理工大学学报（材料科学英文版）

摘　　要：Gelatin microsphere（GMS） was prepared through W/O emulsion chemical-crossline method.The best formula was selected by examining its appearance,size,drug carrier and drug dissolution rate.The experimental results showed that the optimized gelatin microspheres were spherical ball with smooth surface and had well dispersion.The average size of blank gelatin microspheres was 15.84 μm,while the loaded microspheres＇average diameter were 33.10 μm.It was also shown that drug loading of microspheres increased with increasing loading capacity,but drug encapsulation efficiency had a trend of climbing up and then decline.The encapsulation efficiency reached the maximum when the dosage ratio was 2：1.And the results show ceftiofur sodium microspheres have sustained release in the PBS buffer of pH7.4.Gelatin microsphere（GMS） was prepared through W/O emulsion chemical-crossline method.The best formula was selected by examining its appearance,size,drug carrier and drug dissolution rate.The experimental results showed that the optimized gelatin microspheres were spherical ball with smooth surface and had well dispersion.The average size of blank gelatin microspheres was 15.84 μm,while the loaded microspheres＇average diameter were 33.10 μm.It was also shown that drug loading of microspheres increased with increasing loading capacity,but drug encapsulation efficiency had a trend of climbing up and then decline.The encapsulation efficiency reached the maximum when the dosage ratio was 2：1.And the results show ceftiofur sodium microspheres have sustained release in the PBS buffer of pH7.4.

关 键 词：gelatin microspheres surface morphology SIZE drug carrier 

分 类 号：O648.1[理学—物理化学]