二期梅毒患者血清IL-17,IL-23和ROR-γt的检测  

Serum Levels of IL-17,IL-23 and ROR-γt in Patients with Secondary Syphilis

作　　者：朱小霞[1] 程浩[2] 胡勤乐[1] 吕定丰[1] 任雅君[1] 

机构地区：[1]宁波市第一医院皮肤科,浙江宁波315000 [2]浙江大学医学院附属邵逸夫医院皮肤科,浙江杭州300016

出　　处：《中国皮肤性病学杂志》2010年第12期1111-1112,1117,共3页The Chinese Journal of Dermatovenereology

摘　　要：目的检测二期梅毒患者血清IL-17,IL-23和维甲酸受体相关孤儿受体γt(ROR-γt)的水平,探讨Th17细胞在梅毒免疫致病机制中的可能作用。方法采用酶联免疫吸附法检测30例二期梅毒患者和20例正常人血清IL-17,IL-23和ROR-γt水平。结果 30例二期梅毒患者血清IL-17,IL-23和ROR-γt水平分别为(24.8±20.9)pg/mL,(32.1±8.3)pg/mL和(120.2±40.6)pg/mL,均较健康对照[(12.7±14.2)pg/mL,(21.0±8.7)pg/mL,(72.0±41.8)pg/mL]明显升高(P<0.05)。梅毒患者血清IL-17,IL-23和ROR-γt水平与RPR滴度间无线性相关(P>0.05)。结论梅毒患者血清IL-17,IL-23和ROR-γt水平的升高可能与梅毒的免疫致病机制有关。Objective To investigate the serum levels of IL-17,IL-23 and retinoid-related orphan receptor γt （ROR-γt） in patients with secondary syphilis and evaluate the possible role of Th17 cells in the pathogenesis of secondary syphilis. Methods Serum concentrations of IL-17,IL-23 and ROR-γt were determined by ELISA in 30 patients with secondary syphilis and 20 healthy controls. Results Serum concentrations of IL-17,IL-23 and ROR-γt in 30 syphilitic patients were （24.8±20.9） pg/mL,（32.1±8.3） pg/mL and （120.2±40.6） pg/mL,respectively,which were significantly higher than those in healthy controls[（12.7±14.2）pg/mL,（21.0±8.7）pg/mL,（72.0±41.8）pg/mL]（P0.05）. There was no significant relevance between the patients＇ serum levels of IL-17,IL-23,ROR-γt and the RPR titers. Conclusion The increased levels of serum IL-17,IL-23 and ROR-γt in patient may contribute to the immuopathogenesis of secondary syphilis.

关 键 词：梅毒 IL-17 IL-23 ROR-γt 

分 类 号：R759.1[医药卫生—皮肤病学与性病学]