地奈德乳膏联合尿素乳膏治疗手部湿疹疗效和患者生活质量观察  

Efficacy of Desonide Cream Combined with Urea Cream on Chronic Hand Dermatitis and Patients Quality of Life

作　　者：于小兵[1] 贺悦[1] 吴晓金[1] 

机构地区：[1]浙江省皮肤病防治研究所,浙江德清313200

出　　处：《中国皮肤性病学杂志》2010年第12期1177-1178,共2页The Chinese Journal of Dermatovenereology

摘　　要：目的评价地奈德乳膏联合尿素乳膏治疗手部湿疹的疗效和生活质量。方法将入选的91例患者按随机区组法分为对照组(40例)和治疗组(51例),对照组予丁酸氢化可的松乳膏(天津药业集团有限公司生产)联合10%尿素乳膏治疗,治疗组予地奈德乳膏(重庆华邦制药股份有限公司生产)联合10%尿素乳膏(本所自制)治疗,均2次/d,连续用药2周。记录治疗过程中的不良反应,分别于初诊当日和用药2周后记录临床表现,并进行皮肤病患者生活质量指数(DLQI)问卷调查。结果治疗结束治疗组和对照组的有效率分别为92.16%和67.50%,差异有统计学意义(P=0.003)。DLQI问卷调查表明治疗组患者生活质量改善程度优于对照组,差异有统计学意义(P<0.001)。结论地奈德乳膏联合尿素乳膏治疗手部湿疹安全有效,能明显改善患者的生活质量。Objective To evaluate the efficacy of desonide cream combined with urea cream in patients with chronic hand dermatitis and effect on patients quality of life （QoL）. Methods Ninety-one cases patients with chronic hand dermatitis were randomized block into control group（40 cases） and treatment group（51 cases）. Control group receive hydrocortisone butyrate cream combined with 10% urea cream,treatment group receive desonide cream combined with 10% urea cream,both twice daily for 2 consecutive weeks. Adverse effects were recorded at each visit. Clinical manifestation were recorded and questionnaires of Dermatology Life Quality Index （DLQI） to the patients were carried out at the day of preliminary diagnosis and end of treatment. Results At the end of the 2 weeks study,the effective rates for treatment group and control group were 92.16% and 67.50%,with a significant difference between them （P= 0.003）. Questionnaire of DLQI showed that QoL of patients was improved after treatment,nevertheless QoL of patients of treatment group was more significantly improved than that of control group,with a significant difference between the two groups（P0.001）.Conclusion Desonide cream combined with urea cream may be safe and effective for patients with chronic hand dermatitis,can improve the QoL of patients signifcantly.

关 键 词：手部 皮炎 地奈德 生活质量 

分 类 号：R758.23[医药卫生—皮肤病学与性病学]