勃起功能障碍患者血清瘦素水平测定及临床意义  

Determination of serusn leptin level in erectile dysfunction patients and its clinical significance

作　　者：王军凯[1] 徐丹枫[1] 刘玉杉[1] 高轶[1] 车建平[1] 崔心刚[1] 姚亚成[1] 任吉忠[1] 

机构地区：[1]第二军医大学长征医院泌尿外科,全军泌尿外科中心,上海200003

出　　处：《第二军医大学学报》2010年第12期1346-1348,共3页Academic Journal of Second Military Medical University

摘　　要：目的探讨瘦素(leptin)水平与勃起功能障碍(erectile dysfunction,ED)的关系。方法收集门诊主诉为ED的患者38例,分别填写勃起功能国际指数问卷(IIEF-5),评分均<21分,平均(12.3±2.4)分,根据得分高低将患者分为轻、中、重度三组。应用ELISA法分别检测38例患者(患者组)及15名健康成人(对照组)清晨空腹血瘦素水平,记录所有人的身高、体质量,并计算体质指数(body mass index,BMI)。结果患者组和对照组瘦素水平均与BMI明显相关(P<0.05),而与年龄、病史无关;在排除BMI影响的情况下,患者组瘦素值(10.16±8.67)μg/L高于对照组(4.81±3.66)μg/L(P<0.05);同时轻、中、重度三组的瘦素值分别为(6.98±4.99)μg/L、(10.3±9.51)μg/L、(13.1±10.02)μg/L,两两分析显示,中、重度组患者的瘦素水平与轻度组比较均有统计学差异(P<0.05)。结论瘦素水平与ED的发生发展有一定关系。Objective To investigate the association of serum leptin level with erectile dysfunction （ED）.Methods A total of 38 out-patients complaining ED were graded by using IIEF-5 questionnaire.The mean IIEF-5 score of the patients was （12.3±2.4）and no one was higher than 21.The patients were divided into 3 groups according to their scores.The fasting serum leptin levels were determined by ELISA in 38 patients （patient group） and 15 healthy controls （control group）.Their body weights and heights were measured for body mass index（BMI）.Results Serum leptin levels were significantly correlated with BMI in both groups,regardless of patient ages and history.The mean leptin level in patients was （10.16±8.67） μg/L,which was significantly higher than that in the healthy controls （[4.81±3.66] μg/L,P〈0.05） after adjusting the effect of BMI.The leptin levels in the mild,moderate,and severe ED groups were （6.98±4.99） μg/L,（10.3±9.51） μg/L and （13.1±10.02） μg/L,respectively,with that of the mild group being significantly lower than those of the latter two groups（P〈0.05）.Conclusion It is indicated that human serum leptin level may have a potential value in diagnosing ED.

关 键 词：瘦素 体质指数 勃起功能障碍 勃起功能国际指数问卷 

分 类 号：R698[医药卫生—泌尿科学]