血清半胱氨酸蛋白酶抑制剂C、肌酐与脑梗死相关性的研究  

Correlation of serum cystatin C and creatinine levels with cerebral infarction

作　　者：王晓勤[1] 刘存杰[1] 郑菊阳[2] 樊东升[2] 

机构地区：[1]华北煤炭医学院附属医院神经科,唐山063000 [2]北京大学第一医院神经科,北京100083

出　　处：《中华神经医学杂志》2010年第12期1231-1233,共3页Chinese Journal of Neuromedicine

摘　　要：目的 探讨血清半胱氨酸蛋白酶抑制剂C浓度、血清肌酐浓度对脑梗死发病的影响.方法 选择经临床、颅脑CT和（或）MRI确诊的脑梗死患者84例及同期体检正常者76例,酶联免疫法测定血清半胱氨酸蛋白酶抑制剂C浓度,苦味酸法测定肌酐浓度,观察血清半胱氨酸蛋白酶抑制剂C、肌酐与脑梗死发病的关系.结果 脑梗死组血清半胱氨酸蛋白酶抑制剂C的浓度[（1.69±0.60）mg/L]明显低于对照组[（2.00±0.67）mg/L],血清肌酐的浓度[（86.62±14.02）μmol/L]明显高于对照组[（80.88±13.71）μmol/L],比较差异均有统计学意义（P＜0.05）.相关分析显示血清半胱氨酸蛋白酶抑制剂C与脑梗死呈负相关（r=-0.238,P=0.002）,血清肌酐与脑梗死呈正相关（r=0.208,P=0.010）.结论 血清半胱氨酸蛋白酶抑制剂C、肌酐与脑梗死发病相关,半胱氨酸蛋白酶抑制剂C可能是脑梗死发病的一种保护因素,而肌酐可能是脑梗死发病的一种危险因素.Objective To investigate the correlation of serum cystatin C and creatinine levels with cerebral infarction. Methods Eighty-four patients with cerebral infarction diagnosed by clinical manifestations, CT and （or） MRI and 76 healthy subjects were selected. Cystatin C level was tested by enzyme-linked immunosorbent assay （ELISA） and creatinine level was tested by the method of nitroxanthic acid. The correlation of cystatin C and creatinine levels with cerebral infarction was explored. Results The level of serum cystatin C in the cerebral infarction group （1.69±0.60 mg/L） was significantly lower as compared with that in the control group （2.00±0.67 mg/L） （t=-3.084, P=0.002）; the level of serum creatinine in the cerebral infarction group （86.62±14.02 μmol/L） was significantly higher as compared with that in the control group （80.88±13.71 μmol/L） （t=2.611, P=0.010）. Negative correlation between level of serum cystain C and cerebral infarction was noted （r=-0.238, P=0.002）,while the level of serum creatinine was positively related to cerebral infarction （r=0.208, P=0.010）.Conclusion A close correlation between cerebral infarction and both the levels of cystain C and creatinine exists, with cystatin C being a protective factor and creatinine being a risk factor for clinical cerebral infarction.

关 键 词：脑梗死 半胱氦酸蛋白酶抑制剂C 肌酐 

分 类 号：R686[医药卫生—骨科学]