几种中草药对小鼠氟中毒拮抗作用的观察  

Observation on the Antagonism of Some Chinese Herbal Medicine in Mice with Fluorosis

作　　者：韦耀东[1] 罗艳红[1] 温晶[1] 罗义雄[1] 黄靖茜[1] 

机构地区：[1]右江民族医学院,广西百色533000

出　　处：《工业卫生与职业病》2010年第6期332-334,共3页Industrial Health and Occupational Diseases

摘　　要：目的探讨甘草、金银花水提取液对氟中毒小鼠全血中谷胱甘肽过氧化物酶(GSH-Px)活力的影响,初步筛选对氟中毒有治疗作用的中草药。方法将70只昆明种小鼠随机分为对照组、氟中毒组、甘草治疗组、金银花治疗组,实验结束剪尾取血,测全血中GSH-Px活力。结果氟中毒组与对照组比较,全血GSH-Px活力明显降低,差异有统计学意义(P<0.01);对照组与甘草治疗组比较,差异无统计学意义(P>0.05);甘草治疗组与氟中毒组比较,活力明显增强,差异有统计学意义(P<0.01);金银花治疗组与氟中毒组比较,差异无统计学意义(P>0.05);金银花治疗组与对照组比较,活力明显降低(P<0.01)。结论甘草水提取液对氟中毒小鼠全血中GSH-Px活力有明显增强作用,疗效明显,金银花水提取液对氟中毒小鼠全血中GSH-Px活力无明显影响。Objective To investigate the influence of the radix glycyrrhizae and lonicera japonica extract solution on GSH-Px activity in mice with fluorosis,to screen primarily the therapeutic effect of Chinese herbal medicine on fluorosis.Methods 70 mice were randomly divided into 4 groups,i.e.,control group,fluorosis group,radix glycyrrhizae treatment group,lonicera japonica treatment group.The blood GSH-Px activities of every group were determined at the experiment end.Results The blood GSH-Px of fluorosis group was evidently lower than that of the control group（P〈0.01）.Compared the control group with radix glycyrrhizae treatment group,the difference was insignificant（P〉0.05）.The blood GSH-Px of radix glycyrrhizae treatment group was evidently higher than that of fluorosis group,the difference was significant（P〈0.01）.Compared lonicera japonica treatment group with fluorosis group,the difference was insignificant（P〉0.05）.The blood GSH-Px of lonicera japonica treatment group was lower than that of the control group（P〈0.01）.Conclusions Radix glycyrrhizae extract solution could evidently enhance the blood GSH-Px activity in mice with fluorosis,while lonicera japonica extract solution has no obvious influence.

关 键 词：氟中毒 小鼠 GSH-PX 甘草 金银花 

分 类 号：R113[医药卫生—公共卫生与预防医学]