脂肪组织分泌的瘦素通过中枢神经系统调控哺乳动物骨骼代谢的研究进展  

Leptin Derived from Adipose Tissue Regulates Skeletal Metabolism in Mammals via Central Nervous System

作　　者：刘静波[1,2] 陈代文[1,2] 余冰[1,2] 

机构地区：[1]四川农业大学动物营养研究所,雅安625014 [2]动物抗病营养教育部重点实验室,雅安625014

出　　处：《动物营养学报》2010年第6期1482-1487,共6页CHINESE JOURNAL OF ANIMAL NUTRITION

基　　金：教育部创新团队猪抗病营养分子机制研究项目(IRTO555-5)

摘　　要：基因敲除动物模型揭示脂肪组织分泌的瘦素(leptin)在调控骨骼代谢方面发挥着重要作用,进一步研究发现,leptin对骨骼代谢的中枢调节主要通过下丘脑的腹内侧核区域影响成骨细胞的增殖和破骨细胞的分化来完成。本文主要就leptin调控骨吸收和骨形成的相关信号转导途径做一综述,为增进人类骨骼健康提供参考。Gene knockout animal model revealed that leptin derived from adipose tissue played an important role in the regulation of skeletal metabolism.Further researches found that the central regulation of leptin on skeletal metabolism depended on hypothalamic ventromedial nucleus to regulate the proliferation of osteoblast and differentiation of osteoclast.In this paper,related signal transduction pathways of bone absorption and bone formation regulated by leptin are reviewed.The aim of this paper is to provide a reference for further improvement of bone health of human.

关 键 词：瘦素 中枢神经系统 成骨细胞 破骨细胞 骨骼代谢 

分 类 号：S811.2[农业科学—畜牧学]