丹参注射液对哮喘患者的疗效及CD4^+CD25^+调节性T细胞的影响  

Influences of Salvia Miltiorrhiza Injection on clinical efficacy and CD4^+ CD25^+ Regulatory T Cells of asthmatic patients

作　　者：薛克营[1,2] 柯明耀[1,2] 姜燕[1,2] 陈玲玲[1,2] 吴雪梅[1,2] 谢红旗[1,2] 

机构地区：[1]福建省医科大学教学医院 [2]厦门市第二医院厦门市呼吸疾病诊疗中心,福建厦门361021

出　　处：《临床肺科杂志》2011年第1期24-26,共3页Journal of Clinical Pulmonary Medicine

摘　　要：目的观察丹参注射液治疗支气管哮喘(哮喘)患者的疗效及对CD4+CD25+Treg调节性T细胞(CD4+CD25+)的影响,探讨丹参注射液治疗哮喘的新机制。方法 62名哮喘患者随机分成对照组和丹参治疗组,记录试验前、后患者的临床症状评分、FEV1、PEF,流式细胞仪检测患者外周血单个核细胞(PBMCs)中CD4+CD25+Treg的比例。结果两组患者临床症状评分均较治疗前显著减少,治疗组的减少更为明显,且与对照组相比,差异具有显著性(P<0.05);两组患者FEV1、PEF、CD4+CD25+Treg的比例均较治疗前显著增加,治疗组的增加更为明显,且与对照组相比,差异具有显著性(P<0.05)。结论丹参注射液可有效治疗哮喘,其机制可能与促进CD4+CD25+Treg的产生有关。Objective To investigate the influences of Salvia Miltiorrhiza Injection on clinical efficacy and CD4＋ CD25＋ Regulatory T Cells of asthmatic patients,and elucidate the possible mechanism of salvia miltiorrhiza injection in treatment of asthma.Methods 62 asthmatic patients were randomly divided into control group and salvia miltiorrhiza-treated group.The symptom scores,forced expiratory volume in one second（FEV1）and peak flow rate（PEF）were monitored.Flow cytometry was used to detect the CD4＋ CD25＋ Treg ratio in PBMCs.Results Compared with before treatment,symptom scores of two groups significantly decreased（P〈0.05）.The decrease in therapy group was more significant than that in control group（P〈0.05）.Compared with before treatment,FEV1,PEF and CD4＋ CD25＋ Treg ratio of two groups significantly increased（P〈0.05）.The increase in therapy group was more significant than that in control group（P〈0.05）.Conclision Salvia miltiorrhiza injection could treat asthmatic patients effectively,probably by increasing the number of CD4＋ CD25＋ Treg.

关 键 词：丹参注射液 哮喘 CD4+CD25+调节性T细胞 

分 类 号：R259[医药卫生—中西医结合]