葛根素对高血压患者血浆内皮素和一氧化氮的影响  

Effects of puerarin on plasma endothelin and nitric oxide in patients with essential hypertension

作　　者：黄兆铨[1] 叶武[1] 陈申杰[1] 毛威[1] 秦南屏[1] 

机构地区：[1]浙江省中医院心内科,杭州310006

出　　处：《中国现代应用药学》1999年第3期13-15,共3页Chinese Journal of Modern Applied Pharmacy

基　　金：浙江省中医药管理局科研基金资助项目!98B17

摘　　要：目的 :检测正常人与高血压病 (EH)患者血浆内皮素 (ET)、一氧化氮 (NO)的变化及葛根素对其的干预效应。方法 :EH对照组口服苯磺酸氨氯地平 5mg/d ,或合用盐酸苯那普利 1 0mg/d ,每日一次 ,1 5d为一疗程。EH伍用治疗组同时合用 5%GNS2 50ml+葛根素注射液 4 0 0mg静滴 ,两组治疗前后检测血浆ET、NO水平变化。结果 :EH各组血浆ET较正常人组均显著增高 (P <0 .0 1 ) ,血浆NO水平及NO/ET比值除轻度EH组外均显著降低 (P <0 .0 1 ) ,ET和NO水平及NO/ET比值与舒张压程度呈正相关性及负相关性 (r =0 .955,r =-0 .93 1 ,r=-0 .973 )。EH伍用组治疗后与治疗前血浆ET和NO水平有显著差异 (P <0 .0 1 ,0 .0 5) ,与EH对照组治疗后比较 ,血浆ET、NO也有显著差异 (P <0 .0 5)。结论 :葛根素具有显著调节EH患者血浆ET、NO水平作用 。OBJECTIVE:To evaluate the alteration of plasma Endothelin(ET)and Nitric Oxide(NO)in patients with Essential Hypertension(EH),and the involvement of treatment with puerarin.METHODS:Two different treatments were set up as follows:P.0.5mg amlodipine or/and 10mg benazepril(AML or/and BEN),AML or/and BEN combinated with iv gtt 400mg puerarin in 250ml 5% GNS,qd,every 15 days was taken as a treatment course.The alteration of plasma ET and NO was measured before and after the treatments,and the differences between the two groups were compared.RESULTS:Compared with the health control group,the plasma ET of the EH in each group was significantly higher(P<0.05,P< 0.01 ),while the levels of plasma NO and the NO/ET ratio were markedly lower except those in mild EH group(P<0.01),The levels of plasma ET and NO as well as NO/ET ratio were positively or negatively correlated with diastolic blood pressure,respectively(r=0.955,r=-0.931,r=-0.973).There were markedly differences of plasma ET and NO between the two groups(P<0.05),as well as before and after treatment of AML or/and BEN combinated with puerarin,respectively(P<0.01,P<0.05).CONCLUSION:The increased Plasma ET or decreased Plasma NO were well correlated with EH.Puerarin could adjust the levels of plasma ET and NO companying down-adjusting blood pressure effect.

关 键 词：葛根素 高血压 内皮素 一氧化氮 中医药疗法 

分 类 号：R259.441[医药卫生—中西医结合]