Synthesis analogues of milbemycin and their bioactivity evaluation  

作　　者：Jin Hao Zhao Ming Hua Ji Xu Hui Xu Jing Li Cheng Guo Nian Zhu 

机构地区：[1]College of Agriculture and Bioteclmology, Zhejiang University, Hangzhou 310029, China [2]Zhejiang NHU Ltd., Shaoxing 312500, China

出　　处：《Chinese Chemical Letters》2010年第12期1391-1394,共4页中国化学快报（英文版）

基　　金：supported by National Natural Science Foundation of China(No.30700532);the Science and Technology Project of Zhejiang province(No.2008C02007-3).

摘　　要：Eight new 13-O-aminocarbonylivermectin aglycones and 4＇-O-aminocarbonylivermectin monosaccharide were synthesized from ivermectin agiycone and ivermectin monosaccharide by the selective protection of C5-OH group.Their bioactivities were evaluated against spider mites（Tetranychus cinnabarimts）,aphid（Aphis fabae） and oriental armyworm（Mytliimma sepatara）. Their structures were confirmed by ^1H NMR.MS.Eight new 13-O-aminocarbonylivermectin aglycones and 4＇-O-aminocarbonylivermectin monosaccharide were synthesized from ivermectin agiycone and ivermectin monosaccharide by the selective protection of C5-OH group.Their bioactivities were evaluated against spider mites（Tetranychus cinnabarimts）,aphid（Aphis fabae） and oriental armyworm（Mytliimma sepatara）. Their structures were confirmed by ^1H NMR.MS.

关 键 词：13-O-Aminocarbonylivermectin aglycone 4＇-O-Aminocarbonylivermectin monosaccharide SYNTHESIS Insecticidal and acaricidal activities 

分 类 号：TQ457.202[化学工程—农药化工] S859.795[农业科学—临床兽医学]