Asymmetric hydrogenation of aromatic ketones using new chiral-bridged diphosphine/diamine-Ru(Ⅱ) complexes  

作　　者：Yu Ming Cui Lai Lai Wang Fuk Yee Kwong Wei Sun 

机构地区：[1]State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China [2]Open Laboratory of Chirotechnology of the Institute of Molecular Technology for Drug Discovery and Synthesis and Department of Applied Biology and Chemical technology, The Hong Kong Polytechnic University, Hong Kong, China [3]Graduate University of Chinese Academy of Sciences, Beijing 100039, China

出　　处：《Chinese Chemical Letters》2010年第12期1403-1406,共4页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China(Nos.20343005,20473107,20673130,and 20773147);the Hong Kong PolyU Joint Supervision Scheme(A-PH78) for financial support.

摘　　要：A series of chiral secondary alcohols were easily prepared by means of asymmetric hydrogenation of prochiral aromatic ketones using a new（（Rax）-BuP）/（R,R）-DPEN-Ru（Ⅱ） complex catalyst system.The hydrogenation of 2-methylacetophenone in n-butanol （t-BuOK/Ru =45.6/1,S/C = 500,20 atm.of H2,20℃,48 h） afforded（S）-1-（2＇-methylphenyl）ethanol in 92%ee and〉99% conversion.A series of chiral secondary alcohols were easily prepared by means of asymmetric hydrogenation of prochiral aromatic ketones using a new（（Rax）-BuP）/（R,R）-DPEN-Ru（Ⅱ） complex catalyst system.The hydrogenation of 2-methylacetophenone in n-butanol （t-BuOK/Ru =45.6/1,S/C = 500,20 atm.of H2,20℃,48 h） afforded（S）-1-（2＇-methylphenyl）ethanol in 92%ee and〉99% conversion.

关 键 词：Asymmetric hydrogenation Chiral alcohols Diphosphine ligand Ruthenium complexes DIAMINE 

分 类 号：TQ426.94[化学工程] O621.34[理学—有机化学]