维生素A、E对热暴露果蝇保护作用的研究  

STUDIES ON THE PROTECTION OF VITAMINE A AND VITAMINE E ON THE HEAT-EXPOSED DROSOPHILA

作　　者：邱璐[1] 郭俊生[1] 赵法伋[1] 沈志雷[1] 杨林[1] 

机构地区：[1]第二军医大学军队卫生学教研室

出　　处：《解放军预防医学杂志》1999年第3期169-172,共4页Journal of Preventive Medicine of Chinese People's Liberation Army

基　　金：全军医药卫生科研资金

摘　　要：目的：研究脂溶性维生素Ａ、Ｅ能否提高热环境下机体的适应能力以及可能的机制。方法：以果蝇为热暴露模型，分别给予添加低、中、高剂量的ＶＡ或ＶＥ的培养基喂养，观察其在３６．５℃环境中平均生存时间及热应激蛋白（ＨＳＰ７０）含量的变化。结果：低剂量ＶＡ或ＶＥ组的果蝇平均生存时间均显著高于各自的对照组，ＨＳＰ含量的变化亦呈现一致性。结论：较低剂量的ＶＡ或ＶＥ对热暴露环境下的果蝇具有保护作用，这种热保护作用可能与它们能够诱导产生更多的ＨＳＰ有关。Objective: In order to explore the effects of VE and VA on Drosophila by heat exposure and the possible machanism. Methods: Drosophila was used as a model, they were fed with diets at three levels of VA or VE. Survival time and the content of heat shock protein (HSP 70)were tested after Drosophila were exposed at 36.5 in heat environment. Results: Survival time of Drosophila fed at low level of VA or VE significantly increascd when compared with that in control group and the content of HSP 70 also increased. Conclusion: VA or VE could increase the survival time of the heat-exposed Drosophila. It suggested that the heat protection effect of VA or VE might be related to the increase of HSP production.

关 键 词：热暴露 生态时间 热应激蛋白 维生素A 维生素E 

分 类 号：R594.1[医药卫生—内科学] R977.21[医药卫生—临床医学]