Correlation of the Cerebral Microvascular Blood Flow with Brain Temperature and Electro-Acupuncture Stimulation  

作　　者：张栋 李林 马慧敏 叶翠飞 王淑友 陈丁生 

机构地区：[1]Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences [2]Beijing Key Laboratory of Brain Aging, Xuanwu Hospital of Capital Medical University

出　　处：《Journal of Traditional Chinese Medicine》2010年第4期243-248,共6页中医杂志（英文版）

基　　金：supported by a grant from the National Natural Science Fund of China (No. 39770925);Science Research Fund of The Ministry of Personnel for Excellent Returnees (1998);Beijing Key Laboratory Fund of The Science and Technology Commission of Beijing (951890600)

摘　　要：Objective:To investigate the relationship between the temperature and the microvascular blood flow of the cerebral cortex, and the influence of electro-acupuncture (EA) on the cortical microcirculation. Methods: High temperature spots on the anterior ectosylvian and low temperature spots on the posterior suprasylvian on the cortical surface of 20 cats were identified using cortical infrared thermography (CIT); the blood flow in the microcirculation on these spots was measured with laser-Doppler flowmetry. EA was given at Zusanli (ST 36) and changes in the blood flow in the cerebral cortex microcirculation were detected. Results: 1) The mean temperatures on the high (34.83±0.24°C) and low (32.28±0.27°C) temperature spots were significantly different (P<0.001); this was indicative of a temperature difference on the cortical surface; 2) The average blood flow in the microcirculation of the high (266.8±19.2 PU) and low (140.8±9.9 PU) temperature spots was significantly different (P<0.001). 3) On the cortical high temperature spots, the mean blood flow in the microcirculation significantly increased from 266.8±86.8 PU before EA, to 422.5±47.4 PU following 5 minutes of EA (58.35%; P<0.01), and 431.8±52.8 PU 5 minutes after ceasing EA (61.84%; P<0.01). 4) On the low temperature spots, there were no significant differences in blood flow following 5 minutes of EA (146.3±11.5 PU), and 5 minutes after ceasing EA (140.5±11.6 PU), when compared with that before acupuncture (140.8±9.9 PU; P>0.9). Conclusion: The high temperature spots of the cortex are active functional regions of neurons with higher blood flow and a stronger response to EA. EA induces a significant increase in blood flow in the high temperature spots of the cortex.Objective：To investigate the relationship between the temperature and the microvascular blood flow of the cerebral cortex, and the influence of electro-acupuncture （EA） on the cortical microcirculation. Methods： High temperature spots on the anterior ectosylvian and low temperature spots on the posterior suprasylvian on the cortical surface of 20 cats were identified using cortical infrared thermography （CIT）; the blood flow in the microcirculation on these spots was measured with laser-Doppler flowmetry. EA was given at Zusanli （ST 36） and changes in the blood flow in the cerebral cortex microcirculation were detected. Results： 1） The mean temperatures on the high （34.83±0.24°C） and low （32.28±0.27°C） temperature spots were significantly different （P〈0.001）; this was indicative of a temperature difference on the cortical surface; 2） The average blood flow in the microcirculation of the high （266.8±19.2 PU） and low （140.8±9.9 PU） temperature spots was significantly different （P〈0.001）. 3） On the cortical high temperature spots, the mean blood flow in the microcirculation significantly increased from 266.8±86.8 PU before EA, to 422.5±47.4 PU following 5 minutes of EA （58.35%; P〈0.01）, and 431.8±52.8 PU 5 minutes after ceasing EA （61.84%; P〈0.01）. 4） On the low temperature spots, there were no significant differences in blood flow following 5 minutes of EA （146.3±11.5 PU）, and 5 minutes after ceasing EA （140.5±11.6 PU）, when compared with that before acupuncture （140.8±9.9 PU; P〉0.9）. Conclusion： The high temperature spots of the cortex are active functional regions of neurons with higher blood flow and a stronger response to EA. EA induces a significant increase in blood flow in the high temperature spots of the cortex.

关 键 词：cerebral cortex brain temperature  micro-circulation perfusion  electro-acupuncture infrared thermography  laser-Doppler technique 

分 类 号：R245.97[医药卫生—针灸推拿学]