紫外线照射与尿激酶联合应用对犬动脉血栓溶解效应的实验研究  

Thrombolytic effect of ultraviolet combined with urokinase for arterial thrombosis models in canine

作　　者：丁立新[1] 李淑芹[1] 李祚秀[1] 李志立[1] 杨永辉[1] 

机构地区：[1]西安第四军医大学唐都医院康复医学科

出　　处：《中华理疗杂志》1999年第3期150-152,共3页Chinese Journal of Physical Therapy

基　　金：国家自然科学基金

摘　　要：目的：观察紫外线（ＵＶ）局部照射与尿激酶（ＵＫ）联合应用对犬动脉血栓的溶解效应，以及ＵＶ照射参数对其效应的影响规律。方法：复制犬股动脉血栓模型，分别观察单用ＵＫ、及ＵＫ并全光谱ＵＶ局部照射后犬血栓模型溶解情况。结果：与单用ＵＫ相比，联合应用ＵＫ并全光谱ＵＶ局部照射后犬血栓溶通率增高，血栓溶通速度明显加快，血栓溶解程度明显增大，溶通血栓所用ＵＫ剂量显著减少，血栓溶通后血纤维蛋白原水平降低幅度明显减小；大面积ＵＶ照射时，大及中等剂量照射所表现出的溶栓效应明显大于小剂量照射；大剂量ＵＶ、大面积照射的溶栓效应明显大于中等面积照射，即使ＵＶ照射剂量大，但照射面积小时，却不具有明显的促进ＵＫ溶栓效应。结论：动脉血栓形成后立即应用全光谱ＵＶ局部照射可促进ＵＫ的溶栓效应；ＵＶ的这一效应与照射面积与照射剂量之乘积存有正性的量－效关系。Objective: In order to elucidate the thrombolytic effect of combining therapy of ultraviolet(UV)and urokinase(UK) on arterial thrombosis as well as the influence of UV parameters to its effect. Methods: Thrombolytic effect was observed on replicated thrombosis models in canine femoral arteriae either only i.v.administration of UK or combining therapy of UK and UV radiation on skin. Results: With the combining therapy of UK and UV,the thrombolytic rate was increased, the thrombolytic time was shortened,the dosage of UK used was remarkably lowered, which were compared with UK alone.After thrombolysis, the level of plasma fibrinogen was obviously reduced,too.When the skin of large area was radiated by UV, the thrombolytic effect radiated by large dosage was greater than the smaller dosage. Although the skin was radiated with large-dose UV, but the effect wasn't apparent,because of the smaller area radiated only. Conclusion: This study suggests that the UV radiation may promote the thrombolytic effect of UK after thrombosis.The effect is a positive correlation with the UV dosage and UV radiation area.

关 键 词：动脉血栓形成 溶栓效应 紫外线照射 治疗 尿激酶 

分 类 号：R543.05[医药卫生—心血管疾病] R454.2[医药卫生—内科学]