ACE基因插入/缺失多态性对高血压病患者左心室靶器官损害的影响研究  

THE RELATION BETWEEN THE DELETION POLYMORPHISM OF THE ANGIOTENSIN CONVERTING ENZYME GENE AND LEFT VENTRICULAR HYPERTROPHY AND REMODELING IN PATIENTS WITH HYPERTENSION

作　　者：李大庆[1] 张运[1] 马玉燕 张薇[1] 季晓平[1] 黎莉[1] 王勇[1] 邢艳秋[1] 张园园[1] 

机构地区：[1]山东医科大学

出　　处：《山东医科大学学报》1999年第2期132-134,共3页Acta Academiae Medicinae Shandong

摘　　要：为研究ＡＣＥ基因插入缺失多态性对高血压患者左心室靶器官损害的影响，测定６８例高血压病患者的左室重量指数（ＬＶＭＩ）和室壁相对厚度（ＲＷＴ），并应用多聚酶链式反应测定ＡＣＥ基因型。结果表明，经纠正其它影响因素后，ＤＤ型患者ＬＶＭＩ和ＲＷＴ均高于Ｉ型患者（Ｐ＜０．０５）。经多元线性逐步回归分析，ＡＣＥ基因型与ＬＶＭＩ和ＲＷＴ均独立相关（总Ｒ２分别为０．３６和０．４９），ＡＣＥ基因型分别可解释ＬＶＭＩ和ＲＷＴ总变异的３．８％和２％，提示ＡＣＥ基因ＤＤ型是山东籍汉族人高血压病患者左室损害的新的独立危险因素，应重视此类患者的防治。LV mass index and relative wall thickness were calculated in 68 hypertensive patients, ACE genotype were determined by polymerase chain reaction amplification of deoxyribonucleic acid prepared from leukocytes. All patients characteristics were similar across genotype groups. After adjustment for other covariables, the DD genotype were associated with signficantly higher LV mass index and relative wall thickness than was the II genotype. On multiple regression analysis, systolic blood presssure, gender and the ACE genotype were each independently related to LV mass index(R2=0.36), systolic blood pressure, body weigh index and the ACE genotype were each independently related to ralative wall thickness(R2=0.49). The ACE genotype explained an additional 3.8% and 2% of the varitations of LV mass index and relative wall thickness, respectively. In conclusion: the DD genotype of ACE gene maybe a new risk factor in LV hypertrophy and remodeling in Chinese hypertensive population.

关 键 词：高血压 左心室肥大 ACE基因 基因缺失 

分 类 号：R544.1[医药卫生—心血管疾病] R541.3[医药卫生—内科学]