血管紧张素Ⅰ转化酶基因多态和2型糖尿病高血压相关性的研究  

ASSOCIATION BETWEEN AN INSERTION/DELETIONPOLYMORPHISM OF ANGIOTENSIN I CONVERTING ENZYMEGENE AND TYPE 2 DIABETICS WITH HYPERTENSION

作　　者：许玲[1,2] 任建民[1,2] 马玉燕 南海蓉[1,2] 程梅 王德全 

机构地区：[1]山东医科大学附属医院 [2]滨州地区人民医院

出　　处：《山东医科大学学报》1999年第2期147-148,共2页Acta Academiae Medicinae Shandong

摘　　要：为研究血管紧张素Ⅰ转化酶（ＡＣＥ）基因第１６内含子插入／缺失（Ｉ／Ｄ）多态和糖尿病合并高血压的关系，应用ＰＣＲ技术检测４０例中国汉族２型糖尿病高血压患者和４０例无高血压患者ＡＣＥ基因Ｉ／Ｄ多态基因型。结果表明，高血压组和无高血压组相比，Ｄ型等位基因的频率增高（６２．５％ｖｓ４７．５％，χ２＝３．６４，Ｐ＞０．０５，ＯＲ＝１．８４，９５％ＣＩ１．３４～２．５２），但无统计学意义。高血压组ＤＤ基因型的频率也增高（３７．５％ｖｓ１７．５％，χ２＝４．０１，Ｐ＜０．０５，ＯＲ＝２．８３，９５％ＣＩ２．３６～６．７３）。提示携带ＤＤ基因型的２型糖尿病患者有高血压易感性。In order to study the association between an I/D polymorphism of ACE gene and diabetic hypertension, PCR technique was used to determine the ACE gene genotypes in Chinese type 2 diabetics with hypertenison (n=40) and without hypertension (n=40). The results showed that D type allele was prevalent in hypertensive group (62.5% vs 47.5%,2=3.64, P>0.05,OR=1.84,95% CI 1.342.52),but is not statistically different. Distribution of DD genotype is significantly diffetent between the 2 groups (37.5% vs 17.5%,2=4.01, P<0.05,OR=2.83,95% CI 2.366.73).It is suggested that type 2 Chinese diabetics carrying DD genotype are susceptible to hypertension.

关 键 词：糖尿病 高血压 NIDDM ACE 基因 

分 类 号：R587.1[医药卫生—内分泌] R544.1[医药卫生—内科学]