向心性肥胖和糖尿病对绝经后女性垂体促性腺激素细胞分泌功能的影响  

Effects of visceral obesity and diabetes on secretion function of pituitary gonadotroph cells in postmenopausal women

作　　者：李圣贤[1] 刘伟[1] 王丽华[1] 蔡懿婷[1] 邬亦华[1] 成琦[1] 黄融[1] 陈雅文[1] 

机构地区：[1]上海交通大学医学院附属仁济医院内分泌科,上海200127

出　　处：《中国糖尿病杂志》2010年第12期889-893,共5页Chinese Journal of Diabetes

摘　　要：目的探讨向心性肥胖和糖尿病对绝经后女性垂体功能的影响及外周类固醇激素的改变。方法比较正常绝经前妇女(NC1组)、正常绝经后妇女(NC2组)、绝经后糖尿病非肥胖组(DM组)和糖尿病向心性肥胖组(DM+Ob组)的一般临床特征、垂体激素和外周类固醇激素水平的改变。结果 DM+Ob组的血糖、胰岛素、HOMA-IR和TG均较DM组和NC1组、NC2组高(P<0.05)。DM+Ob组和DM组的外周血中,FSH和LH均显著低于NC2组,而且血FSH的浓度在DM+Ob组中也显著低于DM组(P<0.05)。其他垂体前叶激素(ACTH、GH、TSH和PRL)DM+Ob组<DM组<NC组,但差异没有统计学意义(P>0.05)。结论糖尿病合并向心性肥胖的绝经后妇女出现垂体促性腺激素分泌细胞功能受损。Objective To investigate the effects of visceral obesity and diabetes on pituitary function of postmenopausal women. Methods Subjects were divided into four groups： pre-menopausal control （NC1） ,postmenopausal control （NC2）,T2DM without obesity （DM） and T2DM with visceral obesity （DM＋ Oh）. General clinical characteristics, anterior pituitary hormones and steroid hormone of the four groups were compared. Results （1） Serum LH/FSH concerntrations were lower in DM ＋ Ob group than in NC2 group （P〈0.01） ,and Serum FSH concerntration were lower in DM＋Ob group than in DM group （P〈0.05）. （2） Serum levels of ACTH,PRL,GH,TSH were lower in DM group and DM＋Ob group,but the differences didn＇t reach to the significance. （3） There were no significant differences in steroid hormones among the three postmenopausal groups, although the DHEA, E2 and P were significantly decreased as compared with group NCl. Conclusions In the postmenopause women with T2DM, the secretion functions of pituitary gonadotroph ceils are impaired , especially in the subgroup suffering from visceral obesity.

关 键 词：向心性肥胖 糖尿病 绝经 垂体 促性腺激素分泌细胞 

分 类 号：R589[医药卫生—内分泌] R587.1[医药卫生—内科学]