延边地区2型糖尿病患者NAD(P)H氧化酶P22phox C242T基因多态性与颈动脉内膜中层厚度的相关性研究  

Study on correlation between NADPH oxidase p22phox C242T polymorphism and carotid IMT in patients with type 2 diabetes mellitus in Yanbian district

作　　者：李兰[1] 朴莲善[1] 郑寿焕[1] 文英玉[1] 李美子[1] 金京玉[1] 金红梅[1] 

机构地区：[1]延边大学附属医院内分泌科,吉林省延边市133000

出　　处：《中国糖尿病杂志》2010年第12期897-900,共4页Chinese Journal of Diabetes

基　　金：国家自然科学基金资助项目(30460053)

摘　　要：目的研究NAD(P)H氧化酶P22phox C242T基因多态性与延边地区汉族和朝鲜族2型糖尿病(T2DM)及其动脉硬化之间的相关性。方法设立正常对照组(分为汉族亚组、朝鲜族亚组)和T2DM组;T2DM组分为:(1)汉族颈动脉硬化阳性亚组及阴性亚组;(2)朝鲜族颈动脉硬化阳性亚组及阴性亚组。采用PCR-RFLP方法。结果正常对照组汉族和朝鲜族P22phox C242T分布无差异;T2DM组汉族和朝鲜族NAD(P)H氧化酶P22phox C242T群体分布有差异;汉族T2DM患者动脉硬化阳性组与阴性组之间存在CC/CT+TT分布差异。结论 (1)延边地区汉族和朝鲜族T2DM患者的NAD(P)H氧化酶P22phox C242T群体分布具有种族差异。(2)T等位基因为延边地区汉族T2DM动脉硬化的保护基因。Objective To evaluate the association of the C242T polymorphism in p22phox gene of NAD（P）H oxidase with type 2 diabetes mellitus （T2DM）in Han versus Korean population in Yanbian district of China and to observe C242T polymorphism characters of p22phox gene of NAD（P）H oxidase in T2DM patients with atheroselerosis. Methods Han and Korean nationality subgroups suffering from and not suffering from T2DM, with and without carotid atheroselerosis were enrolled and analyzed. The NAD（P） H oxidase P22phox C242T polymorphism was assayed by PCR-RFLP. Results In normal control group, there was no significant difference in the NAD（P）H oxidase P22phox C242T genotype distribution between Han and Korea nationality. In T2DM group, there was significant difference in the NAD（P） H oxidase P22phox C242T genotype distribution between Han and Korea nationality. In T2DM patients of Han nationality, there was significant difference in the genotype distribution of CC and CT＋ TT between patients with and without carotid atherosclerosis. Conclusions 1. There is a significant genotype difference in p22phox gene of NAD（P）H oxidase in T2DM patients between Han population and Korea population in Yanbian district. 2. T allele gene is a protective gene which can prevent against carotid atherosclerosis in T2DM patients of Han population in Yanbian district.

关 键 词：延边地区 糖尿病 2型 NAD(P)H氧化酶P22phox C242T 基因多态性 颈动脉内膜中层厚度 

分 类 号：R587.1[医药卫生—内分泌]