糖尿病足患者血清基质金属蛋白酶2和9及其组织抑制物1水平的改变  

The changes of serum MMP-2,MMP-9 and its tissue inhibitor-1 of matrix metalloproteinase (TIMP-1) in diabetic foot

作　　者：俞红 章惺惺[2] 金美娟 李进 王健 徐亚旗 

机构地区：[1]浙江省长兴县人民医院,313100 [2]温州医学院附属第一医院

出　　处：《中国糖尿病杂志》2010年第12期917-919,共3页Chinese Journal of Diabetes

摘　　要：目的探讨血清基质金属蛋白酶2(MMP-2)、基质金属蛋白酶9(MMP-9)及其组织抑制物1(TIMP-1)与糖尿病足(DF)之间的关联。方法采用酶联免疫吸附法对22例糖尿病足患者(DF组)、23例单纯2型糖尿病患者(T2DM组)及25名健康对照者(NC组)进行MMP-2、MMP-9及TIMP-1水平检测,并分析其关联。结果 DF组MMP-2、MMP-9水平明显高于NC组及T2DM组(P<0.01或P<0.05);DF组及T2DM组TIMP-1水平明显低于NC组(P<0.01或P<0.05),而DF组和T2DM组间无统计学差异(P>0.05);未发现与MMP-2、MMP-9及TIMP-1水平显著相关的临床生化指标。结论 DF患者的MMP-2、MMP-9水平高于单纯T2DM患者,而TIMP-1水平未出现改变。Objective To explore the association of levels of serum matrix matalloproteinase （MMP- 2） and （MMP-9） and its tissue inhibitor-1 of matrix metalloproteinase-1 （TIMP-1） with the pathogenesis of diabetic foot. Methods The levels of serum MMP 2, MMP-9 and TIMP-1 were measured by ELISA in 22 patients with diabetic foot, 23 type 2 diabetic patients without any complications and 25 normal controls. Results The levels of MMP-2 and MMP-9 in diabetic foot patients were extremely higher than in type 2 diabetic patients and controls. The levels of TIMP-1 in patients with diabetic foot and type 2 diabetes mellitus were lower than in controls, while there was no significant difference between diabetic foot patients and type 2 diabetic patients. There was no correlation of MMP-~, MMP-9 and TIMP-1 with indexes of age, BP, lipids, HbA^c, UA and serum ereatinine. Conclusion Patients with diabetic foot have higher levels of MMP2 and MMP-9 than patients with pure diabetes, and have the same level of TIMP-1.

关 键 词：基质金属蛋白酶 糖尿病足 炎症反应 

分 类 号：R587.2[医药卫生—内分泌]