环丁胺-2-羧酸合成工艺的改进  

An Improved Method for Synthesis of Azetidine-2-carboxylic acid

作　　者：金建忠[1] 孙娜波[1] 常东亮[2] 张杰[2] 

机构地区：[1]浙江树人大学生物与环境工程学院,杭州310015 [2]中国科学院嘉兴应用化学研究中心,嘉兴314006

出　　处：《化学通报》2010年第12期1143-1145,共3页Chemistry

基　　金：浙江省科技计划项目(2009C33006)资助

摘　　要：以γ-丁内酯为原料,经过溴代酯化、环合、氢解,制备环丁胺-2-羧酸,总收率42.4%。改进合成工艺已在工厂实现kg级生产,替代了过去50年由天然产物提取的历史。An improved method for synthesis of azetidine-2-carboxylic acid from γ-butyrolactone through bromination,esterification,cyclization and hydrogenation was reported.The overall yield could reach 42.4%.The azetidine-2-carboxylic acid was manufactured on kilograms scale using the reported methodology in stead of traditional extraction from natural plants in the past 50 years.

关 键 词：环丁胺-2-羧酸 合成工艺 叔丁酯 氢解 

分 类 号：TQ235[化学工程—有机化工]