FI、FIS等载体衍生物对兔血小板聚集和TXB_2释放的影响  

Influences of FI,FIS on rabbit platelet aggregation and TXB2 production.

作　　者：杨俊旺[1] 梁永录 刘茵 李文燕 李天锡[2] 李文广[2] 吴勇杰[2] 

机构地区：[1]解放军兰州医学高等专科学校 [2]兰州医学院

出　　处：《兰州医学院学报》1999年第1期10-12,共3页Journal of Lanzhou Medical College

摘　　要：目的通过测定兔血小板聚集和ＴＸＢ２的含量，比较观察Ｆ、Ｉ、ＦＩ、ＦＩＳ在抗血栓方面的药理作用特点。方法用比浊法［４］和放免法［７］测定Ｆ、Ｉ、ＦＩ、ＦＩＳ在体外对兔血小板聚集及释放的ＴＸＢ２的影响。结果连有阿魏酸和吲哚美辛的载体衍生物ＦＩ，ＦＩＳ可抑制ＡＡ、ＡＤＰ诱导的血小板聚集，在１０～２５０μｍｏｌ·Ｌ－１的剂量范围内，两药的作用呈剂量依赖关系，ＦＩ、ＦＩＳ２４０μｍｏｌ·Ｌ－１对ＡＡ和ＡＤＰ诱导的兔血小板聚集的抑制率分别为５９．３２％、５８．５８％和３９．０９％、４９．５６％。ＦＩ、ＦＩＳ２４０μｍｏｌ·Ｌ－１对ＴＸＢ２产生的抑制率分别为４０．６０％、２８．７２％。结论在等分子浓度下，ＦＩ、ＦＩＳ对ＡＡ诱导的兔血小板聚集及其ＴＸＢ２和释放的抑制作用明显强于阿魏酸和吲哚美辛本身。Objective To investigate the effect of IndomethacinumFerulate acid(FI) and IndomethacinumFerulate acidstarch (FIS) on rabbit platelet aggregation induced by ADP and AA and thromboxane B2production. Methods Influences of F,I,FI,FIS on rabbit platelet aggregation and TXB2 production were assaied by born GVR and RIA. Results Both FI and FIS 12.5,60.0,240.0 molL-1,could inhibit the rabbits platelets aggregation induced by adenosin diphosphate (ADP,2.0molL-1),arachidonic acid (AA,33.3 molL-1).Which showed a good doseeffect relationship.The inhibitions by 10300 molL-1 were dependent FI 25.059.32%,FIS 13.1239.09%(ADPinduced),FI 29.96%63.06%),FIS 11.47%39.56%(AAinduced).inhibit the ptoduction of TXB2 as well,(AAinduced)FI 40.60%,FIS 28.74%(240.0 molL-1)for TXB2. Conclusions There are positive correlations between the inhibition of platelet aggregation and TXB2 and effect mechanism on speranskia tuberculata.

关 键 词：阿魏酸 吲哚美辛 血小板聚集 血栓素B2 

分 类 号：R973.2[医药卫生—药品]