1,5-二芳基-3-(2-羟基-4,6-二甲氧基苯基)-2-吡唑啉的合成及氟离子荧光探针行为  

Synthesis of 1,5-Diaryl-3-(2-hydroxyl-4,6-dimethoxylphenyl) -2-pyrazolines as Fluorescent Sensors for Fluoride Ion

作　　者：吴婧[1] 徐助雄[1] 王炳祥[1] 

机构地区：[1]南京师范大学化学与材料科学学院,江苏省生物医药功能材料工程研究中心,江苏省生物功能材料重点实验室,南京210097

出　　处：《高等学校化学学报》2010年第11期2201-2205,共5页Chemical Journal of Chinese Universities

基　　金：江苏省自然科学基金(批准号:BK2008435);江苏省科技重大项目江苏省生物医药材料测试服务平台(批准号:BM2007132)资助

摘　　要：设计合成了8个1,5-二芳基-3-(2-羟基-4,6-二甲氧基苯基)-2-吡唑啉化合物4a～4h.它们的结构经由IR、1H NMR、MS和元素分析确认.测定了它们的紫外光谱和荧光光谱,研究了它们对氟离子的选择性识别作用,发现化合物4a,4c和4d均可选择性地识别氟离子,其中4a和4c作为识别氟离子的荧光探针,受常见离子干扰较小,选择性较高.Fluoride measurements are receiving continuous attention from sensor research communities due to the clinical importance of fluoride levels in biological systems and drinking water.We report the synthesis of eight 1,5-diaryl-3-（2-hydroxyl-4,6-dimethoxylphenyl）-2-pyrazolines（4a—4h） and the studies of them as fluorescent sensors for fluoride ion.The structures of all the products were determined by IR,1H NMR,MS and elemental analysis.Their UV and fluorescence spectra were measured.The influences of four halide ions on their fluorescence properties were studied.Upon addition of other anions such as Cl-,Br-and I-,no significant changes in the fluorescence spectra were observed.However,under identical conditions,the studies show that compounds 4a,4c,4d and 4h had evident fluorescence enhancement with F-.The addition of fluoride ion to compound 4d in DMSO led to a red shift（443—453 nm） and to compound 4h led to a red shift（423—433 nm）.So we have developed two new fluorescent sensors（4a and 4c）.Both of them show high sensitivity and selectivity toward fluoride ion in DMSO.

关 键 词：1 5-二芳基-3-(2-羟基-4 6-二甲氧基苯基)-2-吡唑啉 氟离子 荧光探针 

分 类 号：O629[理学—有机化学]