吸入NO对急性肺栓塞实验性家兔心肌钙蛋白的影响  

THE EFFECT OF NO INHALATION ON THE CARDIAC TROPONIN I OF RABBITS WITH ACUTE MASSIVE PULMONARY EMBOLISM

作　　者：尹娟[1] 张泽明[1] 刘永强[2] 阎琦[1] 

机构地区：[1]河北大学附属医院,保定071000 [2]保定市脑血管病医院

出　　处：《现代预防医学》2011年第1期188-189,共2页Modern Preventive Medicine

摘　　要：[目的]观察NO吸入对急性肺栓塞实验性家兔心肌钙蛋白的影响。[方法]30只家兔随机分为对照组:常规溶栓治疗+蒸馏水吸入组(A组,15只)和治疗组:常规溶栓治疗+NO吸入组(B组,15只),吸入NO浓度为40×10-6g/L。按照自体血凝块法制作家兔急性肺栓塞模型。栓塞后除常规溶栓治疗外即刻两组分别吸入等量蒸馏水和NO,于栓塞前(T1),栓塞后2h(T2)、4h(T3)、12h(T4)、24h(T5)、36h(T6)时抽取动脉血用化学分光法测定血清心肌肌钙蛋白I(cTnI)的浓度。[结果]两组的血清cTnI的浓度在T2、T3、T4、T5、T6时刻均比T1时显著增高(P﹤0.01),组间比较A组的血清cTnI升高幅度明显高于B组(P﹤0.01)。[结论]NO吸入对家兔急性肺栓塞后的心肌损伤有保护作用。[Objective] To observe the effect of NO inhalation on the cardiac troponm l of rabbits with acute massive pulmonary embolism. [ Methods] 30 rabbits were randomly divided into two groups. The control group： routine thrombolysis treatment and distilled water inhalation group （A group, 15） and treatment group： routine thrombolysis treatment and NO inhalation group （B group, 15）, NO density was 40 ×10^-6g/L. According to autoblood clot method, prepared acute pulmonary embolism modle. Alter embolism, two groups were respectively given with inhalation of same quantity distilled water and NO. then detected the concentrations of cardiac troponin before embolism （T1）, 2 hours （T2）, 4 hours （T3）, 12 hours （T4）, 24 hours （1＂5） and 36 hours （T6） after embolism. [ Results] The concentrations of serum cTnI at T2, T3 and T4, T3 and T6 are higher than at T1 point （P 〈 0.01 ）, the increases of serum cTnI in group A are more obvious than those in group B （P 〈 0.01）. [Conclusion] The NO inhalation has protective effect on myocardial damage after acute pulmonary embolism.

关 键 词：吸入NO 家兔 急性肺栓塞. 心肌肌钙蛋白I 

分 类 号：R563.5[医药卫生—呼吸系统]