卡络磺钠注射液与注射用加替沙星的配伍稳定性考察  

Study on the Compatibility of Carbazochrome Sodium Sulfonate Injection and Gatifloxacin for Injection

作　　者：朱雪松[1] 熊秋菊[1] 郑芳[1] 李鹏[1] 

机构地区：[1]郧阳医学院附属东风医院药剂部,十堰市442008

出　　处：《中国药房》2011年第2期149-151,共3页China Pharmacy

摘　　要：目的:考察卡络磺钠注射液与注射用加替沙星在0.9%氯化钠注射液中的配伍稳定性。方法:采用反相高效液相色谱法-二极管阵列检测器同时测定卡络磺钠注射液与注射用加替沙星在0.9%氯化钠注射液中配伍后,分别在25、37℃放置12h内各时间段的含量,并测定pH值,观察配伍液的外观变化。结果:在25、37℃下、12h内,配伍液外观、pH值及含量均无明显变化。结论:在25、37℃下,卡络磺钠注射液与注射用加替沙星在0.9%氯化钠注射液中在12h内可配伍使用。OBJECTIVE： To study the compatibility of Carbazochrome sodium sulfonate injection and Gatifloxacin for injection in 0.9% sodium chloride injection. METHODS： Carbazochrome sodium sulfonate injection was combined with gatifloxacin for injection in 0.9% sodium chloride injection. The contents of carbazochrome sodium sulfonate and gatifloxacin in mixture were determined by RP-HPLC-DAD at 25 ℃ or 37 ℃ within 12 h and external appearance and pH were observed. RESULTS： There was no significant change in appearance, pH and the content of carbazochrome sodium sulfonate and gatifloxacin under two temperature conditions within 12 h. CONCLUSION： Carbazochrome sodium sulfonate injection combined with gatifloxacin for injection in 0.9% sodium chloride injection can be used within 12 h at 25 ℃ and 37 ℃.

关 键 词：反相高效液相色谱法 二极管阵列检测器 卡络磺钠 加替沙星酒己伍 稳定性 

分 类 号：R973.1[医药卫生—药品] R978.1[医药卫生—药学]