抗平喘滴丸质量标准研究  

Study on Quality Standard of Antiasthmatic Dropping Pills

作　　者：周斌[1,2,3] 李雁霞[2] 朱才庆[2] 常军[1] 魏东芝[3] 

机构地区：[1]江西科技师范学院药学院,南昌330013 [2]江西省药物研究所,南昌330029 [3]华东理工大学生物反应器工程国家重点实验室,上海200237

出　　处：《中国实验方剂学杂志》2011年第1期43-45,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：江西省教育厅资助项目(GJJ08516)

摘　　要：目的:建立一种抗平喘滴丸的质量标准。方法:采用薄层色谱(TLC)对处方中药材进行鉴别,采用高效液相色谱(HPLC)测定滴丸中麻黄碱和伪麻黄碱的含量。结果:TLC图谱中可检出苦杏仁、甘草、麻黄的特征图谱,盐酸麻黄碱进样量在0.033 05～0.396 6μg线性关系良好,r=0.999 9,平均回收率99.39%,RSD 2.11%(n=6)。盐酸伪麻黄碱进样量在0.023～0.276μg线性关系良好。r=0.999 7,平均回收率99.89%,RSD 2.55%(n=6)。结论:所建方法简单准确,重复性好,可用于本品的质量控制。Objective ：To set up the quality standard of antiasthmatic dropping pills. Method： TLC was used for identification; ephedrine hydrochloride and pseudoephedrine hydrochloride were determined by HPLC. Result： Prunus armeniaca L. var. ansu Maxim. , Glycyrrhiza uralensis Fisch. and Ephedra sinica Stapf. could be detected by TLC. Ephedrine hydrochloride was linear in the range of 0. 033 05-0. 396 6 μg （r = 0. 999 9） ; the average recovery was 99. 39% （RSD 2. 11% , n =6）. Pseudoephedrine hydrochloride was linear in the range of 0. 023-0. 276 μg （r = 0. 999 7） ; the average recovery was 99.89% （RSD 2.55% , n =6）. Conclusion： The method was simple and accurate with a good reproducibility, and can be used for the quality control of antiasthmatic dropping pills.

关 键 词：平喘 滴丸 高效液相色谱 薄层色谱 麻黄碱 

分 类 号：R284.1[医药卫生—中药学]