芒硝在中药组方中对大黄蒽醌类化合物溶出的影响  

Effect of Mirabilite on Solubility of Content of Anthraquinones in Traditional Chinese Medicine

作　　者：韩刚[1] 郭肖菲[1] 赵会新[1] 肖倩[1] 赵媛[1] 喇万英[1] 

机构地区：[1]华北煤炭医学院药学系,河北唐山063000

出　　处：《中国实验方剂学杂志》2011年第1期72-74,77,共4页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:研究芒硝在大承气汤、调胃承气汤中对大黄中蒽醌类化合物溶出的影响,揭示芒硝在煎煮过程中对药物成分溶出的影响。方法:采用传统煎煮的方法分别煎煮大黄、大承气汤、小承气汤、大黄甘草汤、调胃承气汤,高效液相色谱法测定各煎煮液中游离蒽醌及结合蒽醌类化合物的含量。结果:在相同的条件下,中药组方中大黄与芒硝煎煮时,可影响大黄蒽醌类化合物的溶出。结论:大黄与芒硝煎煮时,芒硝可使大黄中蒽醌类化合物的溶出量减少。Objective ： To explore the effect of mirabilite on solubility of anthraquinones in Dachengqi decoction and Xiaochengqi decoction. Method： To prepare Dachengqi decocction and Xiaochengqi decoction with traditional method, the content of anthraquinones was determined with high porformence lilquid chromatograph. Result： In the same conditions the content of anthraquinounes was decreased when mirabilite was added. Conclusion： Mirabilite can decrease the solubility of anthraqunones when the mirabilite decocted with rhubarb.

关 键 词：芒硝 大黄 蒽醌 配伍 大承气汤 调胃承气汤 高效液相色谱 

分 类 号：R283.6[医药卫生—中药学]