敦煌石室大宝胶囊对衰老大鼠脑组织钙稳态的影响  

Influences of Dunhuang Shishi Dabao capsule(DHDB) on calcium homeostasis in bra in tissue of the aging rats

作　　者：程容[1] 段永强[1] 成映霞 梁玉杰 朱立鸣 

机构地区：[1]甘肃中医学院基础课部,甘肃兰州730020

出　　处：《中国老年学杂志》2010年第23期3514-3516,共3页Chinese Journal of Gerontology

基　　金：甘肃省科技攻关计划项目(2GS064-A43-020-22);兰州市科技局计划项目(06-2-87)

摘　　要：目的探讨敦煌石室大宝胶囊对衰老模型大鼠脑组织钙稳态的影响。方法采用D-半乳糖建立大鼠衰老模型,测定大脑组织内Na+-K+-ATPase、Ca2+-ATPase、Ca2+-Mg2+-ATPase活性和Ca2+含量。结果模型组大鼠脑组织内Na+-K+-ATPase、Ca2+-ATPase、Ca2+-Mg2+-AT-Pase活性显著降低,Ca2+含量显著升高(P<0.01,P<0.05);应用敦煌石室大宝胶囊治疗后,治疗组大鼠脑组织内Na+-K+-ATPase、Ca2+-ATPase、Ca2+-Mg2+-ATPase活性增高,Ca2+含量显著降低(P<0.01,P<0.05)。结论敦煌石室大宝胶囊具有调节衰老大鼠脑组织钙稳态的作用。Objective To explore the effect of Dunhuang Shishi Dabao（DHDB） capsule on calcium homeostasis in brain tissue of the aging model rats.Methods The subacute aging model rats were made by injecting D-gal into abdominal cavity continually,and Na＋-K＋-ATPase,Ca2＋-ATPase,Ca2＋-Mg2＋-ATPase and Ca2＋ levels in brain tissue were evaluated.Results The model group hand the downregulated Na＋-K＋-ATPase,Ca2＋-ATPase and Ca2＋-Mg2＋-ATPase levels（P0.01,P0.05）,and the significantly increased Ca2＋ levels（P0.05）.After treated with DHDB, Na＋-K＋-ATPase,Ca2＋-ATPase,Ca2＋-Mg2＋-ATPase levels were upregulated（P0.05,P0.01）,Ca2＋ levels was reduced significantly（P0.05）.Conclusions DHDB can regulate calcium homeostasis in aging rats′brain.

关 键 词：钙稳态 衰老模型 大鼠 敦煌石室大宝胶囊 

分 类 号：R285.5[医药卫生—中药学]