壳聚糖硫酸盐催化合成尼泊金甲酯  

SYNTHESIS OF METHYLNIPAGIN ESTER CATALYZED BY CHITOSAN SULFATE

作　　者：尹大伟[1] 苗东琳[2] 刘玉婷[1] 

机构地区：[1]陕西科技大学化学与化工学院,陕西西安710021 [2]陕西咸阳偏转集团德隆泰克公司,陕西咸阳712021

出　　处：《精细石油化工》2010年第6期49-52,共4页Speciality Petrochemicals

基　　金：陕西科技大学博士基金资助课题(05-1)

摘　　要：以壳聚糖硫酸盐为催化剂合成了尼泊金甲酯。考察了壳聚糖脱乙酰度的影响因素及壳聚糖硫酸盐的催化活性。最佳酯化反应条件为:n(甲醇):n(对羟基苯甲酸)=4:1,壳聚糖硫酸盐用量为对羟基苯甲酸质量的0.93%,回流反应4 h,产物收率达93.1%。该催化剂用于合成尼泊金甲酯具有良好的催化活性和重复使用性。Methyl nipagin ester was synthesized using chitosan sulfate as catalyst. The deacetylation degree of chitosan, reaction conditions of sulfuric acid alkylation, catalytic activity, dosage of cata- lyst, reaction time, and the ratio of alcohol to acid on the yield of methyl nipagin ester were carefully studied. Through orthogonally arranged experiments, the optimal conditions were obtained as fol- lows： molar ratio of methanol to acid = 4 to 1, 0. 93~ catalyst based on the mass of acid, reaction time under refluxing 4 h. Under these conditions, the yield of the esterification reached 93.1~. The results showed that chitosan sulfate had excellent catalytic activity and could be used repeatedly.

关 键 词：壳聚糖 壳聚糖磺酸盐 催化剂 尼泊金甲酯 对羟基苯甲酸 甲醇 

分 类 号：TQ426.94[化学工程]