猪肝动脉的弹性模量与性别的关系  

Relationship between the elastic modulus of the hepatic artery and gender

作　　者：李静[1] 李文春[1] 宋杰[2] 王明华[3] 王磊[3] 王汉琴[1] 黄铁柱[1] 

机构地区：[1]湖北医药学院人体解剖学教研室 [2]湖北医药学院附属东风医院,十堰442000 [3]湖北医药学院附属太和医院

出　　处：《中国临床解剖学杂志》2010年第6期686-689,共4页Chinese Journal of Clinical Anatomy

基　　金：湖北省高等学校优秀中青年科技创新团队项目(T201008);湖北省教育厅科学技术研究项目(D200924003);湖北医药学院研究生启动基金项目(2008QDJ8)

摘　　要：目的探讨猪肝动脉弹性模量与性别的关系,为猪到人异种肝移植提供理论依据。方法取23例4、7月龄雌性、雄性、去势湖北白猪的肝动脉,将其按从近心端到远心端的方向分成近、中、远3段,各段置于4℃冰箱中待用。在软组织生物力学试验机上测定中段动脉的压力-直径关系,计算出增量弹性模量(Einc)、压力-应变弹性模量(Ep)和容积弹性模量(Ev)。结果 7月龄各组肝动脉的弹性模量有显著性差异(P<0.01):雌性组最低,雄性组居中,去势组最高;7月龄各组与4月龄各组的弹性模量相比显著减小(P<0.05)。结论 7月龄不同性别猪肝动脉弹性模量存在差异,从生物力学方面考虑,在猪到人异种肝移植时,应选择性别相匹配的猪肝脏作为供体材料,使移植材料肝动脉间的弹性模量尽可能相近,降低肝动脉并发症,有可能提高移植肝的存活率。Objective To explore the relationship between the gender and the elastic modulus of the hepatic artery of pigs and to provide theoretical basis for pig-to-human transplantation.Methods The hepatic artery of female,male and gonadectomized 23 Hubei white pigs aged between 4 and 7 months were obtained,and then,the arteries were divided into the upper,middle and lower segments,kept at 4℃.The pressure-diameter relationship of the middle segment was measured on the biomechanical testing system for soft tissues,and the elastic modulus was calculated,including press strain elastic modulus（Ep）,incremental elastic modulus（Einc）,and volume elastic modulus（Ev）.Results The difference of hepatic arterial elastic modulus among female,male and gonadectomized groups was significant（P〈0.01）,with the lowest of female group,the highest of gonadectomized group and the middle of male group.The hepatic arterial elastic modulus in all groups aged 7 months was lower than that in all groups aged 4 months,and the difference was significant（P〈0.05）.Conclusions There is the sex difference of the hepatic arterial elastic modulus in all pigs aged 7 months,which suggests that gender mathching pig liver should be selected as the donor organs,for keeping the same elastic modulus between the donor and receptor and reduce the hepatic arterial complications after liver xenotransplantation.

关 键 词：猪 肝动脉 弹性模量 生物力学 异种移植 

分 类 号：R318.01[医药卫生—生物医学工程]