抗病毒免疫中宿主细胞的自溶作用以及病毒的进化  

Autophagy in Host Cells and Evolution Strategy of Virus in Anti-virus Immunity

作　　者：陈炅然[1] 严作廷[1] 尚若峰[1] 崔颖[1] 李宏胜[1] 

机构地区：[1]中国农业科学院兰州畜牧与兽药研究所,甘肃兰州730050

出　　处：《动物医学进展》2010年第12期132-137,共6页Progress In Veterinary Medicine

基　　金：中央级公益性科研院所基本科研业务费专项资金项目(BRF090403);"十一五"国家科技支撑计划(2008BADB4B01-2)

摘　　要：多种病原体能够侵害宿主细胞并从宿主的机体免疫系统的防御下得以逃逸。在宿主细胞中,病原体利用一些复杂的方法和途径避免了细胞对入侵者强有力的攻击。近年来的研究表明,自噬作用是细胞内宿主细胞杀灭入侵病原微生物的防御结构中最显著的工具之一,有些病原体却可以在分子水平阻滞这种自噬通路而使持续感染成为可能。宿主抗病毒反应中自噬作用与先天免疫和获得性免疫之间,以及病毒与自噬作用之间存在着复杂的相互关系,这些关系主导了自噬作用和病原菌之间的相互作用。Numerous pathogens have possessed the capacity to invade host cells protected from components of the systemic immune system.However,once in the host cells pathogens utilize sophisticated strategies to avoid the powerful machinery built by the host cells to kill invading pathogens.There are cumulative evidence indicating that autophagy is one of the most remarkable tools of the intracellular host cell defense machinery that bacteria must confront upon cell invasion in the last few years.However,several pathogens overthrow the autophagic pathway by operating this process at the molecular level,as a strategy to establish a persistent infection.There is complicated interrelationship among autophagy,inative immunity and adaptive immunity system,as well as virus and autophagy,which dominates the interaction between autophagy and pathogens.

关 键 词：自噬作用 病原体 宿主细胞 免疫 

分 类 号：S852.4[农业科学—基础兽医学]