川崎病患儿血小板激活参数和凝血功能检测及意义  

Determination of Platelet Activation Parameters and Blood Coagulation in Kawasaki Disease and Their Clinical Significance

作　　者：黎赛[1] 莫丽亚[1] 杨丽华[2] 宋春荣[1] 周舟[1] 刘建良[1] 

机构地区：[1]湖南省儿童医院检验科,湖南长沙410007 [2]湖南省临床检验中心

出　　处：《实用预防医学》2010年第11期2285-2287,共3页Practical Preventive Medicine

摘　　要：目的探讨血小板活化及凝血功能检测在川崎病(KD)诊疗中的意义。方法收集川崎病患儿40例于治疗前及治疗后检测平均血小板内容物浓度(MPC)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)、凝血酶时间(TT)、凝血酶原时间(PT);40例健康儿童为对照组。结果 KD组患儿治疗前及治疗后MPC水平显著低于正常对照组(P<0.05)。KD组患儿治疗前FIB水平显著高于正常对照组(P<0.05),治疗后FIB水平回复正常(P>0.05)。其余结果比较,差异均无统计学意义(P>0.05)。结论 FIB与活化的血小板相互作用促进了KD急性冠状动脉血栓的形成。KD治疗前MPC降低和FIB增高可作为KD早期辅助诊断的重要指标。在KD诊疗中观测MPC与FIB水平有助于临床及时了解病情,判断预后及转归。Objective To explore the clinical value of detecting platelet activation and blood coagulation in children with Kawasaki disease（KD）. Methods Forty children with KD were enrolled in the study.The levels of mean platelet component（MPC）,APTT,PT,FIB and TT in the children were determined before and after the treatment.40 children with normal physical examination were served as control group. Results Compared with control group,the levels of MPC were significantly decreased in children with KD before and after the treatment,（P〈0.05）.Before the treatment,plasma level of FIB in KD group was significantly higher than that in control group（P〈0.05）,but after the treatment,plasma level of FIB came back to normal（P〈0.05）.No statistically significant difference was found in the others results between the two groups（P〉0.05）. Conclusions Plasma FIB and activated platelets affect each other and might take part in the pathogenesis of KD.As the important markers,decreasing MPC and increasing plasma FIB in KD children before the treatment might be served as auxiliary diagnosis of early stage of KD.Observing the levels of MPC and plasma FIB can help clinical doctors know the progress and prediction of KD.

关 键 词：黏膜皮肤淋巴结综合征(川崎病) 血小板活化 平均血小板内容物浓度 凝血功能 纤维蛋白原 

分 类 号：R446.11[医药卫生—诊断学]