离子液体[Etpy]BF_4催化苯并咪唑类化合物的微波合成及其抗菌活性  

Catalytic Synthesis and Antibacterial Activity of Benzimidazole Compounds by Ionic Liquid [Etpy]BF_4 under Microwave Irradiation

作　　者：张璇[1] 付玉杰[1] 祖元刚[1] 余平[1] 陈玥[1] 刘晓蕾[1] 

机构地区：[1]东北林业大学林业生物制剂教育部工程研究中心森林植物生态学教育部重点实验室,黑龙江哈尔滨150040

出　　处：《合成化学》2010年第6期691-694,699,共5页Chinese Journal of Synthetic Chemistry

基　　金：中央高校基本科研业务费专项资金资助项目(RL10BA05)

摘　　要：在微波辐射下,离子液体[Etpy]BF4催化邻苯二胺与取代芳醛(或直链醛)的反应,合成了12个2-取代苯并咪唑类化合物(2a^2 l),其结构经1H NMR,IR和MS表征。最佳反应条件为:邻苯二胺1 mmol,芳醛1mmol,无水乙醇6 mL,[Etpy]BF40.2 mmol,于25℃/500 W反应2 h^3 h,产率78.6%~97.7%。初步生物活性测试结果表明,部分化合物对革兰氏阴性菌和革兰氏阳性菌都具有较好的抑制活性。Twelve benzimidazole compounds（2a^2l） were synthesized by the reaction of 1,2-phenylenediamine and substituted-aromatic aldehyde（or linear aldehyde） under microwave irradiation using ionic liquid [Etpy]BF4 as the catalyst.The structures were characterized by 1H NMR,IR and MS.The optimum reactions at 25 ℃/500 W for 2 h-3 h were as followed： 1,2-phenylenediamine was 1 mmol;aromatic aldehyde was 1 mmol;EtOH was 6 mL;[Etpy]BF4 was 0.2 mmol.The yield were 78.6%～97.7% under the optimum reactions.Preliminary biological activity test showed that some of them exhibited good bacterium activities anti-Gram positive and anti-Gram negative.

关 键 词：离子液体 邻苯二胺 醛 苯并咪唑 微波合成 抗菌活性 

分 类 号：TQ463.53[化学工程—制药化工]