安徽省肾综合征出血热沙鼠肾细胞Ⅰ型灭活疫苗免疫性及其流行病学效果的考核  

Evaluation on the Efficacy of Immunization and Epidemiology of Type Ⅰ Inactivated Vaccines against HFRS in An Hui Province

作　　者：王以银[1,2,3,4] 刘红[1,2,3,4] 任次早 宋明宇 吴炳权[1,2,3,4] 韩远荣 魏强 黄玉有 谢杰[1,2,3,4] 李芙蓉 戴振威 罗兆庄[1,2,3,4] 

机构地区：[1]安徽省卫生防疫站 [2]霍邱县卫生防疫站 [3]颖上县卫生防疫站 [4]六安市卫生防疫站

出　　处：《中国公共卫生》1999年第7期594-596,共3页Chinese Journal of Public Health

摘　　要：采用ＥＬＩＳＡ、ＩＦＡ检测特异性抗体，ＭＣＰＥＮＴ检测中和抗体和ＨＩ，进行血清学分型。结果：选择姬鼠型疫区，接种沙鼠肾细胞Ⅰ型灭活出血热疫苗安全性较好。免疫后４２天ＨＦＲＳ．Ｖ．ＩｇＧ抗体阳性率为９６４３％，ＧＭＴ＝３５１８，１８０天有明显下降，加强免疫两周后阳性率达１００％，而且１２００天仍有３６３６％人群存在１∶１０（＋）抗体；ＭＣＰＥＮＴ抗体较ＩＦＡ抗体阳性率低，但疫苗免疫人群具有特异性回忆反应。中期流行病学防病效果接种组发病率为２３５／１０万，对照组为４２９３／１０万，保护率９４５３％。The purpose was to observe the safety,immunity,middle term epidemiological efficacy of TypeⅠ Inactivated Vaccines against HFRS prepared from tissue of Monqolian gerbils kidney.ELISA,IFA were used in testing specific antibody in sera.MCPENT was used in testing neutralization antibody.HI was used in assaying serological type.It was proved safe that the population who lived in the wild rodent epidemic area were inoculated vaccines.The seroconversion rate of HFRS.V.IgG antibody was 96 43%,GMT=35.18(42 days after primary immunization).The former dropped apparently on 180th day.The rate of seroconversion was 100%(two weeks after reinforced immunization).The 36.36% of them were still tested HFRS.V.IgG antibody(1∶10) on 1200th day.The seroconversion rate of specific antibody by MCPENT was less than by IFA.The specific reminiscence reaction was existed among the immunizated population.The epidemioloigcal effect of middle term.The incidence rate of inoculation group was 2.35/100 000 and that of the control group was 42.93/100,000.The protection rate of the vaccine was 94.53%.The result was showed safe that the population of epidemic area were inoculated the Type Ⅰ vaccine gainst HFRS.The epidemiological effect of middle term was satisfied.

关 键 词：肾综合征出血热 灭活疫苗 免疫效果 疫苗 

分 类 号：R512.803[医药卫生—内科学]