CXCR1、CXCR2及其配体的结构和功能  

Structure and function of CXCR1,CXCR2 and their ligands

作　　者：毕惠娟[1] 王健[1] 

机构地区：[1]安徽理工大学医学院病原学与免疫学教研室,淮南232001

出　　处：《免疫学杂志》2010年第12期1091-1095,共5页Immunological Journal

基　　金：安徽省自然科学基金(090413138);安徽省教育厅自然基金重点项目(KJ2009A032;KJ2007A019);安徽省教育厅自然基金重点项目(KJ2010A086)

摘　　要：CXCR1、CXCR2主要表达于中性粒细胞、单核细胞、T细胞等细胞表面,属G蛋白偶联受体超家族成员,可与CX-CL1、CXCL2、CXCL3、CXCL5、CXCL6、CXCL7、CXCL8结合。当两者结合后,通过G蛋白变构激活下游的效应分子进行信号转导,介导细胞发生迁移、脱颗粒等一系列生物学效应,在多种炎症性疾病中发挥重要作用。此外,尚有调节细胞发育、新生血管生成和趋化组织细胞及肿瘤细胞等作用。CXCR1 and CXCR2,two important members of G protein-coupled receptors superfamily,are mostly expressed on mature PMN,monocytes,T cells and other immunocytes.CXCR1 and CXCR2 can bind to different ligands,such as CXCL1,CXCL2,CXCL3,CXCL5,CXCL6,CXCL7,and CXCL8.As CXCR1 and CXCR2 are combined with their ligands,intracellular signal transduction can be induced by allosteric G protein molecules and a series of downstream biological effects of cell migration and degranulation have been established.Latest research shows that CXCR1 and CXCR2 play a key role not only in multiple inflammatory diseases but also in cell development,angiogenesis and chemotactic of normal histiocytes and abnormal tumor cells.

关 键 词：CXC趋化因子受体1 CXC趋化因子受体2 CXC趋化因子 

分 类 号：R392.1[医药卫生—免疫学]