HIV/AIDS患者结核感染预防性治疗效果评价研究  

Efficacy of prophylactic treatment for tuberculosis infection in patients with HIV/AIDS

作　　者：殷继国[1] 何卫华[1] 练祖银[1] 刘焰东[1] 周沛林[1] 萧爱清[2] 刘凤仁[3] 

机构地区：[1]湖北省随州市疾病预防控制中心,随州441300 [2]湖北省疾病预防控制中心结核病防治所,武汉430079 [3]华中科技大学同济医学院公共卫生学院,武汉430030

出　　处：《中国防痨杂志》2010年第12期791-794,共4页Chinese Journal of Antituberculosis

基　　金：湖北省科学技术攻关项目(2006AA301C50)

摘　　要：目的了解异烟肼预防性治疗对HIV/AIDS患者结核感染的预防性效果。方法对湖北省随州市2006年符合预防性治疗标准的HIV/AIDS患者进行9个月的异烟肼预防性治疗,随访观察其治疗结果并与2005年的相关资料进行对比分析。结果对HIV总人群来说,异烟肼预防性治疗对预防结核的发生(P=0.18)及病例的死亡无显著影响(P=0.06),但对PPD(+)的HIV患者的死亡(P=0.03)与结核发病有明显的保护作用(P=0.00),且不良反应轻微。结论 PPD(+)的HIV患者实施9个月的异烟肼预防性治疗是切实可行的,具有明显的保护效果。Objective To investigate the efficacy of prophylactic treatment with Isoniazid for tuberculosis infection in patients with HIV/AIDS.Methods Participants who were enrolled according to the prophylactic treatment standard in Suizhou City of Hubei province were treated with Isoniazid for nine months in 2006,and were followed-up for treatment outcomes.The data were compared with that of 2005.Results For all HIV-infected patients,9 month Isoniazid Treatment had no protection regarding to tuberculosis morbidity（P=0.18） and mortality（P=0.06）.For HIV（＋） and PPD（＋） patients,it had significant protection on tuberculosis morbidity（P=0.00） and HIV related mortality（P=0.03）,and side effects were slight.Conclusion It is practicable to perform 9 month Isoniazid prophylactic treatment on HIV（＋） PPD（＋） patients,and has obvious protective effect.

关 键 词：获得性免疫缺陷综合征 结核/预防和控制 治疗结果 

分 类 号：R512.91[医药卫生—内科学]