天然药物防治非酒精性和酒精性脂肪肝的研究进展  

Treatment of nonalcoholic and alcoholic fatty liver diseases by single natural drug and active natural products: research advances

作　　者：赵昱[1] 刘蜻蜻[2] 徐艳[3] 李凤贤[2] 彭芳[1] 巫秀美[1] 曾苏[3] 刘光明[1] 

机构地区：[1]大理学院药学院云南省高校昆虫药物研究重点实验室,大理671000 [2]大理学院附属医院,大理671000 [3]浙江大学药学院中药与天然药物研究室,杭州310058

出　　处：《国际药学研究杂志》2010年第6期408-425,共18页Journal of International Pharmaceutical Research

基　　金：云南省高层次人才培引工程(2009CI121);云南省科技厅重点产业创新工程(中药现代化科技产业云南基地建设)项目(2008IF012);国家教育部长江学者奖励计划(2000);浙江大学985人才专项基金(2000)

摘　　要：本文综述了近年来天然药物、有效部位及单体活性成分用于治疗非酒精性脂肪肝和酒精性脂肪肝的研究进展。文中列举了122种天然药物的治疗效果,并将其分为生物碱类、总黄酮和总酚酸类、单体酚酸、萜类和甾醇类、总苷与总酯类、氨基酸和杂环类、多糖与聚糖类、肽和不饱和脂肪酸类、香豆素和色素类、单味植物药制剂、动物药与真菌药共11大类。文中还对未来非酒精性脂肪肝和酒精性脂肪肝的新药研发方向进行了评述。This paper reviews the recent research progress on the utilization of natural drugs against nonalcoholic fatty liver diseases（NAFLD）and alcoholic fatty liver diseases （AFLD）. A total of 122 species of natural drugs, confined to the effective extracts of single herbal or animal drug and the active single natural products, were summarized and categorized as alkaloids,total flavonoids and total phenolics,single phenolics, terpenoids and steroids, total glycosides and total esters, amino acids and heterocycles, polysaccharides and proteoglycans, polypeptides/glycopeptides and poly-unsaturated fatty acids, coumarins and phenomens, single herbal drug, animal and fungus drugs. The future tendency of new natural drug research and development against NAFLD and AFLD is also discussed and some afforded suggestions were provided.

关 键 词：天然药物 有效部位 单体活性成分 脂肪肝 非酒精性 脂肪肝 酒精性 脂肪肝 治疗药物 新药研发 

分 类 号：R259[医药卫生—中西医结合]