贝那普利联合硝普钠辅治慢性肺源性心脏病急性加重期的疗效观察  

The effect observation of benazepril combined with sodium nitroprusside in acute exacerbation of chronic pulmonary heart disease

作　　者：李海成 骆明光[1] 

机构地区：[1]广东省吴川市人民医院,525400

出　　处：《临床合理用药杂志》2010年第23期3-4,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察贝那普利联合硝普钠辅治慢性肺源性心脏病急性加重期的临床效果。方法将慢性肺源性心脏病急性加重期患者50例随机分为观察组和对照组,每组25例。对照组给予常规治疗,观察组给予贝那普利联合硝普钠治疗。治疗后比较2组疗效及动脉CO2分压(PaCO2)、血氧饱和度(SpO2)、动脉血氧分压(PaO2)、心脏每搏输出量(SV)、每分输出量(CO)、左室射血分数(LVEF)水平。结果观察组总有效率为96.0%高于对照组的68.0%,差异有统计学意义(P<0.05)。治疗后2组患者PaO2、SaO2及PaCO2水平均较治疗前改善(P<0.05);且观察组优于对照组(P<0.05)。治疗后2组患者SV、CO及LVEF水平均较治疗前改善(P<0.05);且观察组优于对照组(P<0.05)。2组均未见明显的药物不良反应。结论贝那普利联合硝普钠辅治慢性肺源性心脏病急性加重期的疗效较好,无明显不良反应,值得临床推广应用。Objective To investigate the effect of benazepril combined with sodium nitroprusside in acute exacerbation of chronic pulmonary heart disease.Methods 50 cases patients with acute exacerbation of chronic pulmonary heart disease were divided into the observation group and the control group,each of 25 cases.The control group received the normal treatment,and the observation group received the treatment of benazepril combined with sodium nitroprusside.After treatment,compared effect and PaCO2,SpO2,PaO2,SV,CO,LVEF level of two groups.Results The total effective rate of observation group（96.0%）was higher than that in control group（68.0%）,the difference was statistically significant（P〈0.05）.After treatment,PaO2,SaO2 and PaCO2 of two groups improved（P〈0.05）,and observation group was better than control group（P〈0.05）.After treatment,SV,CO and LVEF of two groups improved（P〈0.05）,and observation group was better than control group（P〈0.05）.There was no obvious adverse drug reactions in two groups.Conclusion It has a good effect that benazepril combined with sodium nitroprusside in acute exacerbation of chronic pulmonary heart disease.

关 键 词：贝那普利 硝普钠 心脏病 慢性 肺源性 

分 类 号：R541.5[医药卫生—心血管疾病]