氧化苦参碱聚氰基丙烯酸正丁酯纳米粒的体外释药及肝脏分布研究  

In vitro release and the liver targeting of oxymatrine polybutylcyanoacrylate nanoparticles

作　　者：葛亮[1] 卢曼[1] 陈跃坚[1] 陈艳华[1] 

机构地区：[1]中国药科大学药学院,南京210009

出　　处：《中国药科大学学报》2010年第6期520-523,共4页Journal of China Pharmaceutical University

基　　金：中国药科大学青年自然科学基金资助项目(No.2J10026)~~

摘　　要：制备了氧化苦参碱聚氰基丙烯酸正丁酯纳米粒(OM-PBCA-NP),采用透析法观察OM-PBCA-NP体外释药行为,通过小鼠尾静脉注射氧化苦参碱溶液(OM-SOL)和OM-PBCA-NP,考察两种制剂在血液和肝脏中的分布。结果表明,氧化苦参碱溶液在体外4h内已释放完全,而OM-PBCA-NP4h仅释放出总药量的36.73%;OM-PBCA-NP与氧化苦参碱水溶液小鼠静脉注射后在肝脏中的AUC之比为8.338。结果表明,OM-PBCA-NP不仅可以缓慢释药,而且具有一定的肝靶向性。Oxymatrine（OM） polybutylcyanoacrylate nanoparticles（OM-PBCA-NP） was prepared,and in vitro release of OM-PBCA-NP as well as the liver targeting potentials of OM-PBCA-NP and oxymatrine solution（OM-SOL） were studied in mice.It was found that 100% of OM was released from OM solution in 4 h,but only 36.73% from OM-PBCA-NP.In the study of tissue distribution of OM-PBCA-NP,there existed 8.338-fold increase in the area under the liver concentration-time curve in comparison to that of OM-SOL.Hence,OM-PBCA-NP sustained drug release and increased the liver targeting significantly.

关 键 词：氧化苦参碱 纳米粒 聚氰基丙烯酸正丁酯 体外释放 肝靶向 

分 类 号：R944[医药卫生—药剂学]