缩宫素对胎鼠脑缺氧损伤的保护作用  

Protective effect of oxytocin on hypoxia damaged fetus rat

作　　者：于红[1] 陆廷凤[2] 沈杨[1] 任慕兰[1] 王少华[3] 

机构地区：[1]东南大学附属中大医院妇产科 [2]东南大学临床医学院 [3]东南大学附属中大医院内分泌科,南京210009

出　　处：《中国药科大学学报》2010年第6期568-571,共4页Journal of China Pharmaceutical University

基　　金：江苏省自然科学基金资助项目(No.BK2008302)~~

摘　　要：围产期胎儿缺氧、缺血可导致婴儿神经系统异常。用无糖、缺氧人工脑脊液培养胎鼠脑切片造成脑细胞损伤模型,研究缩宫素的保护作用。电镜观察显示,缩宫素可使细胞凋亡明显减少;免疫组化测定结果显示缩宫素可使胎鼠海马CA3区缩宫素受体(OTR)和γ-氨基丁酸A受体β1亚基(GABAARβ1)明显增多。实验结果表明缩宫素对胎鼠缺氧、缺血神经元的损伤有保护作用。Perinatal hypoxia may induce some neural disease of infants.Damage model of fetus rat brain was made by incubation in oxygen and glucose deprived artificial cerebrosinal for the investigation of the protective effect of oxytocin.Electron micrograph showed that oxytocin could decrease the apoptosis.Results of immunohistochemistry experiments showed that oxytocin could increase oxytocin receptor（OTR） and gamma-aminobutyric acid receptor A β1 subunit（GABA_ARβ1）.It was concluded that oxytocin possessed protective effect on neurone damage of fetus rats.

关 键 词：缩宫素 海马 γ-氨基丁酸A受体β1亚基 脑缺氧损伤 保护 

分 类 号：R965[医药卫生—药理学]