半去势雄性大鼠外周血中睾酮代偿性变化的研究  

Semi-castrated male rats compensatory changes in peripheral blood of testosterone

作　　者：顾亚楠[1] 沙地克.沙吾提 阿地力江.伊明 潘建春[2] 胡永玮[1] 努尔巴提[1] 冯震[2] 

机构地区：[1]新疆医科大学 [2]新疆医科大学人体解剖学教研室,新疆乌鲁木齐830011

出　　处：《新疆医科大学学报》2010年第11期1280-1282,共3页Journal of Xinjiang Medical University

基　　金：国家博士后项目(20100471677);新疆高校科研计划科学研究重点资助项目(XJEDU2010I35)

摘　　要：目的研究半去势雄性大鼠外周血中睾酮水平变化规律。方法取20只性功能正常的雄性SD大鼠,随机分为正常组与半去势组(n=10),分别行右侧睾丸摘除术与假手术后,第2,3、5、7、9周放射免疫法检测外周血中睾酮(T)、促黄体生成素(LH)、促卵泡刺激素(FSH)含量。结果在各时间段内,半去势组T含量显著低于正常组(P<0.05),半去势组第7周显著高于第2、3、5、9周(P<0.05),正常组各周间差异则无统计学意义(P>0.05)。半去势组LH在2、3、5、7、9周后均显著高于正常组(P<0.05),在各时间段内,半去势组第7周显著高于2、3、5、9周(P<0.05),而第3、5周与第9周间差异无统计学意义(P>0.05)。半去势组与正常组间FSH含量差异无统计学意义(P>0.05),半去势组2、3、5、7、9周间差异亦无统计学意义(P>0.05)结论半去势后T水平显著降低,其代偿性升高于现象9周后回落,其代偿机制可能与LH相关。Objective To study the semi-castrated male rats changes of testosterone levels in peripheral blood.Methods 20 normal male sexual function SD rats were randomly divided into normal group and the semi-castrated group（n=10）,excision of the right testis were performed with the sham operation,the first 2,3,5,7 9 weeks radioimmunoassay in peripheral blood testosterone（T）,luteinizing hormone（LH）,follicle stimulating hormone（FSH） content.Results In each period,semi-castrated group T was significantly lower than the normal group（P〈0.05）,half of the ovariectomized group at 7th week were higher than 2,3,5,9 weeks（P〈0.05）,the normal group there was no significant difference between weeks（P〉0.05）.Semi-castrated group at 2,3,5,7,9 weeks after the LH were significantly higher than the normal group（P〈0.05）,in each period,half of the ovariectomized group was significantly higher than the first 7 weeks 2,3,5,9 weeks（P〈0.05）,and the first 3,5 weeks and the first 9 weeks was no significant difference between（P〉0.05）.Semi-castrated group and normal FSH levels between groups was no significant difference（P〉0.05）,semi-castrated group 2,3,5,7,9 There was no significant difference between weeks（P〉0.05） Conclusion The semi-castrated T levels were significantly reduced,the compensatory increase of the phenomenon after 9 weeks in fall,and its compensatory mechanisms may be associated with the LH.

关 键 词：半去势 睾酮 促黄体生成素 促卵泡刺激素 

分 类 号：R657.3[医药卫生—外科学]