水杨醛双Schiff碱与其铜配合物的合成与抗菌活性研究  

Synthesis and Biological Activity of Salicylaldehyde Schiff Base and Cu(Ⅱ) Complexes

作　　者：蔡丽华[1] 张丹[1,2] 黄丽芬[1] 朱静静[1] 

机构地区：[1]中南民族大学工商学院环生系,湖北武汉430065 [2]中南民族大学生命科学学院,湖北武汉430074

出　　处：《广东化工》2010年第12期212-213,215,共3页Guangdong Chemical Industry

摘　　要：文章首先合成了水杨醛双Schiff碱N,N’-双(2-水杨醛亚胺基乙基)-2,6-吡啶二甲酰胺(Ⅱa),并以它为配体合成了铜配合物,通过波谱分析对其结构进行了表征。并采用固体培养基抑菌圈法和液体培养基比浊法对了Schiff碱及其铜配合物进行抗菌活性的测定。结果表明,水杨醛双Schiff碱及其铜配合物对大肠杆菌和金黄色葡萄球菌均有抗菌活性,并且水杨醛双Schiff碱铜配合物的抗菌活性比水杨醛双Schiff碱的抗菌活性强。In the paper, we took fractional steps and synthesized linear multidentate Schiff base ligand [N,N-bis（2-Salicylaldehyde-iminoethyl）- 2,6-pyridinedicarboxylic diamide （IIa）] firstly, then the Cu（II）complexes linked by Schiff base were synthesized. The ligand and complex were characterized by spectra. The antibacterial activity and minimum inhibitory concentrate tests on E. Coli and Staphylococcus aureus of the Schiff base and its Cu （II） complexes were carried out. The results showed that： Schiff base and its Cu（II） Complexes have a certain degree of antibacterial activity, but the Cu（II） Complexes have a better antibacterial activity.

关 键 词：水杨醛 SCHIFF碱 铜配合物 合成 抗菌活性 

分 类 号：O627.41[理学—有机化学]