预注罗库溴铵对顺式阿曲库铵快速诱导期肌松效应的影响  

Effect of Pre-injection of Rocuronium on Rapid Neuromuscular Blocking Induced by Cis-atracurium

作　　者：谢柯祺[1] 兰志勋[2] 蔡兵[2] 范丹[2] 曾思[2] 

机构地区：[1]泸州医学院,泸州市646000 [2]四川省医学科学院/四川省人民医院麻醉科,成都市610072

出　　处：《中国药房》2010年第48期4529-4531,共3页China Pharmacy

基　　金：四川省卫生厅科研基金资助项目(080350)

摘　　要：目的:探讨预注罗库溴铵对顺式阿曲库铵快速诱导期肌松效应的影响。方法:选择开腹手术的患者80例,随机均分为4组:Ⅰ组预注氯化钠注射液3mL;Ⅱ、Ⅲ、Ⅳ组分别预注罗库溴铵0.03、0.06、0.09mg·kg-1。各组间隔3min后,使用顺式阿曲库铵快速诱导,当T1抑制100%时行气管插管。分别记录血流动力学参数、起效时间、插管条件及恢复时相指标。结果:与Ⅰ组比较,Ⅱ、Ⅲ、Ⅳ组血流动力学参数变化无显著性差异(P>0.05);Ⅱ、Ⅲ、Ⅳ组均可将顺式阿曲库铵起效时间缩短(P<0.01),其中Ⅳ组最为明显,为(136.5±22.3)s;4组患者恢复时相指标的差异无统计学意义(P>0.05),其值分别为T539.1～59.9min、T2543.0～63.5min。结论:预注罗库溴铵可缩短顺式阿曲库铵起效时间,且不影响顺式阿曲库铵恢复时相。OBJECTIVE：To observe the effect of the pre-injection of rocuronium on rapid neuromuscular blocking induced by cis-atracurium.METHODS：80 patients underwent abdominal surgery were collected and randomly divided into 4 groups：group Ⅰ was given pre-injection of normal saline 3 mL;group Ⅱ,group Ⅲ and group Ⅳ were given pre-injection of rocuronium with dose of 0.03,0.06,0.09 mg·kg-1 respectively.In 4 groups,neuromuscular blocking was induced rapidly by cis-atracurium 3 minutes later.When T1 of 100% was inhibited,endotracheal intubation should be conducted.The change of hemodynamics,onset time,intubation conditions and T5,T25 were recorded.RESULTS：Compared with group Ⅰ,hemodynamics parameters of group Ⅱ,group Ⅲ and group Ⅳ had no obvious change（P0.05）;the onset time of cis-atracurium could be shortened（P0.01）,especially in group Ⅳ with onset time of（136.5±22.3） s.The difference of T5,T25 among 4 groups were not significant（P0.05）,and T5 and T25 were 39.1-59.9 min and 43.0-63.5 min respectively.CONCLUSION：Pre-injection of rocuronium can significantly reduce the onset time of cis-atracurium and dosen＇t affect recovery phase.

关 键 词：罗库溴铵 顺式阿曲库铵 预注剂量 起效时间 恢复时相 

分 类 号：R614[医药卫生—麻醉学]