微波辐射固体酸催化合成4-芳基二氢香豆素  

Study of the Synthesis of 4-Aryl-3,4-dihydrocoumarins Catalyzed by Solid Acid (SiO_2-H_2SO_4) under Microwave Irradiation

作　　者：张燕[1] 吴过[1] 陈涛[1] 王存德[1] 

机构地区：[1]扬州大学化学化工学院,江苏扬州225002

出　　处：《广州化工》2010年第12期94-96,共3页GuangZhou Chemical Industry

基　　金：江苏省自然科学基金资助(BK2008216)

摘　　要：以硅胶负载硫酸为固体酸催化剂,使用微波辐射促进桂皮酸和酚类化合物的Pechmann反应合成4-芳基-3,4-二氢香豆素。通过改变微波的功率、催化剂的用量、溶剂的种类及用量等因素研究反应的最优条件。在所优选的反应条件下,获得收率为33.2%~88.0%的系列4-芳基-3,4-二氢香豆素。Some 4-aryl-3,4-dihydrocoumarins were synthesized via Pechmann reaction from phenols and substituted cinnamic acids in the presence of solid acid（（SiO2）n-OSO3H） under microwave irradiation.The influence of reaction conditions on yields was also tested using the reaction of cinnamic acid and phenol as a model reaction,and the optimum conditions were obtained.In the optimum conditions,the desired products were obtained in the yield of 33.2%~88.0%.

关 键 词：香豆素 桂皮酸 固体酸催化剂 微波反应 Pechmann反应 

分 类 号：O643.36[理学—物理化学]