孕早期吸入安氟醚对子代大鼠认知功能的影Ⅱ向  

Effect of inhalation of enflurane in early pregnancy on cognitive function in offsprings of rats

作　　者：刘军武[1] 赵为禄[1] 罗佛全[1] 

机构地区：[1]南昌大学第一附属医院麻醉科,330006

出　　处：《中华麻醉学杂志》2010年第9期1076-1077,共2页Chinese Journal of Anesthesiology

基　　金：江西省科技支撑计划重点项目（2009BSA09700）

摘　　要：目的 探讨孕早期吸入安氟醚对子代大鼠认知功能的影响.方法 孕8～10 d SD大鼠30只,随机分为对照组（C组）、吸入安氟醚4 h组（E1组）和吸入安氟醚8 h组（E2组）,每组10只.E1组和E2组分别吸入1.7%安氟醚4和8 h,氧流量2 L/min,C组吸入等流量氧气.于出生后20和30 d,采用Morris水迷宫实验测试子代大鼠的认知功能.结果 与C组比较,E1组和E2组出生后20和30 d时子代大鼠认知功能测试第3至5天逃避潜伏期延长,穿越平台次数减少,平台象限停留时间缩短（P＜0.05）;E1组和E2组子代大鼠上述指标差异无统计学意义（P＞0.05）.结论 孕早期吸入安氟醚可降低子代大鼠的认知功能.Objective To investigate the effect of inhalation of enflurane in the early pregnancy on the cognitive function in the offsprings of rats. Methods Thirty 8-10 day pregnant SD rats were randomly divided into 3 groups （ n = 10 each）： control group （group C）, 4 h inhalation of enflurane group （group E1 ） and 8 h inhalation of enflurane group （group E2）. Group E1 and E2 inhaled 1.7% entlurane （in O2 2 L/min） for 4 and 8 h respectively, while group C inhaled oxygen 2 L/min for 8 h. The learning and memory functions of the offsprings were assessed at 20 and 30 days after birth by Morris water maze test. Results Compared with group C, the escape latency was significantly prolonged, the frequency of crossing the original platform was significantly decreased and the staying time at the original platform quadrant was significantly shortened at 3-5 days after the test in group E1 and E2 （ P 〈 0.05）. There was no significant difference in the indexes metioned above between group E1 and E2 （ P 〉 0.05）. Conclusion Inhalation of enflurane in the early pregnancy can result in cognitive dysfunction in the offsprings of the rats.

关 键 词：麻醉药 吸入 妊娠初期 认知 

分 类 号：R614[医药卫生—麻醉学]