2型糖尿病胫前黑斑患者T淋巴细胞亚群变化的探讨  

Study on T lymphocyte Function in Type 2 Diabetes Mellitus Patients with Black Patches on Pre-tibia

作　　者：敖小凤[1,2] 高志红[1] 邱明才[1] 何庆[1] 

机构地区：[1]天津医科大学总医院内分泌科,300052 [2]海洋石油总医院内科

出　　处：《天津医药》2010年第12期1056-1058,共3页Tianjin Medical Journal

摘　　要：目的:了解2型糖尿病(T2DM)胫前黑斑患者的T淋巴细胞亚群变化以及微血管病变情况。方法:根据有无胫前黑斑将64例糖尿病患者分为有斑组34例及无斑组30例,并与48例健康体检者对照(对照组),自动分析仪测定血糖、血脂代谢指标,流式细胞计数法测定外周血CD3+、CD4+、CD8+T细胞,并比较T2DM有斑组与无斑组微血管病发生率。结果:3组间TC、HDL-C、LDL-C差异无统计学意义(均P>0.05),无斑组及有斑组TG、FG、HbA1c明显高于对照组(P<0.05),无斑组及有斑组TG、FG、HbA1c差异无统计学意义(均P>0.05)。3组间CD3+差异无统计学意义,无斑组与对照组CD4+、CD4+/CD8+、CD8+差异无统计学意义(P>0.05),有斑组CD4+、CD4+/CD8+较对照组及无斑组升高,CD8+较对照组及无斑组降低(P<0.01或P<0.05)。有斑组微血管病变发生率高于无斑组(64.7%vs36.7%,P<0.05)。结论:胫前黑斑可能是T2DM患者免疫异常及微血管病变在皮肤的表现,皮肤黑斑及其他微血管并发症的发生可能与体内细胞免疫异常有关。Objective：To investigate T lymphocyte function and prevalence of microangiopathy in type 2 diabetes mellitus（T2DM） patients with black patches on pre-tibia.Methods：Data of metabolism of glucose and lipid were collected.The percentages of CD3＋ to total lymphocytes,CD4＋ and CD8＋ to T lymphocytes were measured by flow cytometry.The incidence of microangiopathy was compared between non-black-patch group and black-patch group.Results：There were no significant differences in cholesterol（TC）,high density lipoprotein（HDL）-C and low-density lipoprotein（LDL）-C between three groups（P 0.05）.The levels of triacylglycerol（TG）,fasting blood glucose（FG） and glycosylated hemoglobin（HbA1c） were higher in black-patch group and non-black-patch group than those in control group（P 0.05）.There were no differences in TG,FG and HbA1c between black-patch group and non-lack-patch group（P 0.05）.The percentage of CD3＋ to total lymphocytes were similar in the three groups（P 0.05）.There were no differences in CD4＋,CD4＋/CD8＋ and CD8＋ between non-black-patch group and control group（P 0.05）.The percentage of CD8＋ to T lymphocytes was significantly lower in black-patch group than that in control group and non-black-patch group（P 0.01 or P 0.05）.The percentage of CD4＋ and the ratio of CD4＋/CD8＋ were both significantly higher in black-patch group than those in control group and non-black-patch group（P 0.01 or P 0.05）.The incidence of chronic complications,especially microangiopathy,was significantly higher in black-patch group than that in non-black-patch group（P 0.05）.Conclusion：CD4＋ T lymphocytes were activated in T2DM patients with black patches on pre-tibia.Black patches on pre-tibia could be a dermatic sign of immune disorder and microangiopathy in T2DM.Black patches and other microangiopathy could be related to disorder of cyto-immune function in T2DM.

关 键 词：糖尿病 2型 色素沉着过多 胫骨 T淋巴细胞亚群 糖尿病血管病变 脂类 血糖 

分 类 号：R563.1[医药卫生—呼吸系统]