钾通道激动剂对抗原诱发哮喘豚鼠气道阻力及气道炎症的作用  

The effects of potassium channel activator on antigen induced airway spasm and inflammatory cells infiltration in sensitized guinea pig

作　　者：石昭泉[1,2,3] 张美琪[1,2,3] 修清玉[1,2,3] 颜泽敏[1,2,3] 朱琦 罗文侗[1,2,3] 叶曜芩 陈艺坛[1,2,3] 

机构地区：[1]第二军医大学长征医院呼吸内科 [2]第二军医大学长征医院实验诊断科 [3]解放军第92医院内科

出　　处：《第二军医大学学报》1999年第3期184-186,F004,共3页Academic Journal of Second Military Medical University

基　　金：国家自然科学基金

摘　　要：目的：探讨钾通道激动剂在哮喘防治中的作用。方法：测定哮喘动物模型气道阻力、肺泡灌洗液细胞计数及病理检查，观察钾通道激动剂ＢＲＬ５５８３４对气道阻力及气道炎性细胞浸润的影响，并与对照剂二甲亚砜（ＤＭＳＯ）、氨茶碱、ＢＲＬ３８２２７及维拉帕米比较。结果：预先静注ＢＲＬ５５８３４可抑制卵蛋白诱发致敏豚鼠气道痉挛，减轻气道炎性细胞浸润，对血压无明显影响；ＢＲＬ３８２２７及氨茶碱均能抑制炎性细胞浸润，氨茶碱还能抑制卵蛋白诱发的气道痉挛，但ＢＲＬ３８２２７可降低豚鼠血压；维拉帕米对卵蛋白诱发的气道痉挛及炎性细胞浸润均无抑制作用。结论：钾通道激动剂ＢＲＬ５５８３４具有气道相对选择性，抑制抗原所致气道阻力升高及气道炎性细胞浸润，且对心血管系统无明显影响，具有临床应用前景。Objective: To study the role of potassium channel activator in treatment of asthma. Methods: Airway insufflation pressure measurement(AIP), bronchial alveolar lavage fluid(BALF) cells count and pathological analysis were employed to detect airway resistance variation and airway inflammatory cells infiltration following inhalation of ovalbumin. Results: BRL 55834(8 μg/kg) inhibited not only ovalbumin induced AIP increase but also inflammatory cells infiltration in sensitized guinea pigs, it did not lower blood pressure. By contrast to BRL 55834, BRL 38227 (200 μg/kg) and aminophylline(25 mg/kg) inhibited ovalbumin induced inflammatory cells infiltration, but BRL 38227 lowered blood pressure markedly. Verapamil (0.5 mg/kg) had no effects on AIP increasing and inflammatory cells infiltration. Conclusions: BRL 55834, a selective potassium channel activator, not only decreases airway resistance, but also inhibits inflammatory cells infiltration, and this is beneficial for treatment of asthma.

关 键 词：钾通道激动剂 哮喘 豚鼠 气道阻力 气道炎症 

分 类 号：R562.25[医药卫生—呼吸系统]