心型脂肪酸结合蛋白和缺血修饰白蛋白对急性冠脉综合征的诊断价值  

Value of heart-type fatty acid binding protein and ischemia modified albumin in diagnosis of acute coronary syndrome

作　　者：李洁琪[1] 何成毓[1] 李晓翔[1] 彭虹[1] 

机构地区：[1]贵阳医学院附属医院心内科,550004

出　　处：《实用医学杂志》2010年第23期4322-4324,共3页The Journal of Practical Medicine

基　　金：教育部新世纪人才支持计划项目(编号:NCET-08-0650);贵州省优秀科技教育人才省长基金项目[编号:黔省专合字(2008)88号]

摘　　要：目的:探讨心型脂肪酸结合蛋白(H-FABP)和缺血修饰白蛋白(IMA)在急性冠脉综合征(ACS)诊断中的应用价值。方法:检测135例胸痛患者H-FABP、IMA、心肌肌钙蛋白(cTnT)水平,按发病时间分为<3h、3～6h、6～12h时段,计算各项指标诊断ACS的灵敏度及特异度。结果:H-FABP、IMA在<3h时间段诊断ACS的灵敏度分别为40.0%和52.0%,在3～6h时间段的灵敏度分别为53.3%和50.0%,H-FABP联合IMA灵敏度分别为64.0%和75.0%,均优于cTnT(P<0.001),在6～12h段H-FABP与cTnT差异无显著性,IMA灵敏度明显降低。三项指标诊断ACS的特异度比较差异无统计学意义。结论:H-FABP、IMA对ACS诊断有较高的灵敏度和特异度,H-FABP联合IMA可明显提高ACS早期诊断的敏感性。Objective To explore diagnostic value of heart-type fatty acid binding protein（H-FABP） and ischemia modified albumin（IMA） for acute coronary syndrome（ACS）. Methods To observe 135 patients with acute chest pain. Data of H-FABP,IMA and cardiac troponin （cTnT） were detected within 12 hours after the symptoms appeared,their diagnostic sensitivities for ACS were evaluated. Results The sensitivities of H-FABP and IMA within 3 hours were 40.0% and 52.0% respectively,in 3 ～ 6 hours were 53.3% and 50.0% respectively. The sensitivity of combination of H-FABP and IMA was 64.0%（within 3 h） and 75.0%（in 3 ～ 6 h）,which was higher than that of cTnT（P 〈0.001）. In 6 ～ 12 hours,there was no significant difference among H-FABP,IMA and cTnT in specificity of ACS. Conclusion H-FABP and IMA has more sensitivity and specificity for early diagnosis of ACS,they can improve the early diagnostic sensitivity of ACS significantly.

关 键 词：冠状动脉疾病 缺血修饰白蛋白 心型脂肪酸结合蛋白 CTNT 诊断 

分 类 号：R541.4[医药卫生—心血管疾病]