比较替米沙坦与卡托普利对有高血压的代谢综合征患者颈动脉内膜中层厚度及脂联素水平的影响  

Effects of telmisartan on carotid intima-media thickness and adiponectin level in hypertensive pa- tients with metabolic syndrome

作　　者：周桦[1] 黄菊芬[1] 张文君[1] 王贤明[1] 张忠磊[1] 刘建新[1] 

机构地区：[1]湖北医药学院附属太和医院,湖北十堰442000

出　　处：《临床内科杂志》2010年第12期818-820,共3页Journal of Clinical Internal Medicine

摘　　要：目的探讨瞥米沙坦对有高血压的代谢综合征患者动脉粥样硬化进展及血脂联素水平的影响。方法入选84例有高血压的代谢综合征患者，随机分为替米沙坦组和卡托普利组，两组患者接受十日应药物治疗6个月，对比两组患者在用药前后颈动脉内膜中层厚度、血脂联素水平等指标的变化情况。结果药物治疗6个月后替米沙坦组患者血脂联素水平[（2．8±0．7）mg／L]明湿高于卡托背利组患者[（0．8±0．6）mg／L，P=0．033]，同时与卡托普利比较，替米沙坦在降低颈动脉内膜中层厚度方面显示更为有效的趋势[（0．06±0．07）mm，（0．03±0．06）mm]。结论与卡托普利比较，替米沙埘能史有效地提高有商血压的代谢综合征患者血脂联素的水平，抑制动脉粥样硬化的进展。Objective The aims of this study were to compare the effect of telmisartan and captopril on the plasma levels of adiponectin and the carotid intima-media thickness（CIMT） in hypertensive patients with metabolic syndrome. Methods Eighty-four hypertensive patients with metabolic syndrome were enrolled in this study. Patients were randomized to receive treatment with telmisartan（n = 43） or captopri] （n =41 ） for 6 months. Adiponectin and the CIMT were measured at the study entry and 6 month follow- up. Results There were no significant differences on the levels of adiponectin and CIMT between the two groups at baseline. After six months,the adiponectin concentrations increased significantly in the telmisartan group r （2.8 ± 0.7 ） vs （0.8 ±0.6） mg/L, P = 0. 033 ]. The decreasing tendency of CIMT was observed in the telmisartan group at 6 months when compared to the captopril group [ （0.06 ± 0.07 ） vs （0.03 ± 0.06） mini. Conclusions Tehnisartan could increase the serum inhibit the progression of carotid artery intima-media thickness in hypertensive patients with metabolic syndrome.

关 键 词：高血压 替米沙坦 颈动脉内膜中层厚度 脂联素 

分 类 号：R544.1[医药卫生—心血管疾病]